Category: 510758-28-8

《Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA》 was written by Kour, Smit; Rana, Sandeep; Kizhake, Smitha; Lagundzin, Dragana; Klinkebiel, David; Mallareddy, Jayapal Reddy; Huxford, Tom; Woods, Nicholas T.; Natarajan, Amarnath. Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineThis research focused ontumor necrosis factor alpha stapling protein RELA nuclear translocation. The article conveys some information:

Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-ΚB subunit RELA has been implicated in several pathol. conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to inhibit TNFα-induced nuclear translocation. This is a previously unexplored strategy to inhibit TNFα-induced NF-ΚB activation. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Dalton Transactions included an article by Tran, Thi V.; Couture, Garret; Do, Loi H.. SDS of cas: 510758-28-8. The article was titled 《Evaluation of dicopper azacryptand complexes in aqueous CuAAC reactions and their tolerance toward biological thiols》. The information in the text is summarized as follows:

Dicopper azacryptand complexes were evaluated in Cu-catalyzed azide-alkyne cycloaddition (CuAAC) in H2O at 37°. They showed high activity at concentrations ≥5 μM. These dinuclear catalysts were more susceptible toward inhibition by cysteine rather than glutathione under the conditions tested. The mononuclear Cu complexes that are ligated by tripodal amine ligands, also exhibited good catalytic activity in aqueous media and showed similar sensitivity toward biol. thiols as that of the dinuclear complexes. The results suggest that the azacryptand catalysts are too structurally flexible to adequately prevent interactions of their metal centers with external nucleophiles. However, further steric tuning of the ligand structure might enable more effective substrate gating in future studies. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Triazolyl C-nucleosides via the intermediacy of β-1′-ethynyl-2′-deoxyribose derived from a Nicholas reaction: Synthesis, photophysical properties and interaction with BSA》 were Bag, Subhendu Sekhar; Das, Suman Kalyan. And the article was published in Tetrahedron in 2019. Synthetic Route of C30H30N10 The author mentioned the following in the article:

We report the design and synthesis of triazolyl donor/acceptor unnatural C-nucleosides via alkyne (sugar)-azide (aromatic) 1, 3-dipolar cycloaddition reaction as a key step and studies on their photophys. properties. We have chosen β-1′-ethynyl-2′-deoxyribose as a precursor to synthesize triazolyl-C-nucleosides. Overcoming the difficulties, we obtain β-1′-ethynyl-2′-deoxyribose as a major product following a Co2(CO)8 catalyzed intramol. Nicholas reaction. The 1,3-diaxial interaction is the driving force for the α to β-anomeric conversion while performing cobalt complexation followed by oxidation to afford β-1′- ethynyl-2′-deoxyribose as the major product. A Cu(I)-catalyzed click reaction between different aromatic donor/acceptor azides and β-1′- ethynyl-2′-deoxyribose generates the desired unnatural triazolyl donor-acceptor aromatic C-nucleosides (cTBDo/Ac) within 30 min. Single crystal X-ray structure shows the puckered conformation of sugar as C3′-exo. Studies on the photophys. properties suggests good fluorophoric as well as solvatochromic characteristics of these nucleosides. Two of the synthesized nucleosides, cTAnthBDo and cTPyBDo, are found to interact with BSA as the only tested protein with quenching of fluorescence signal. The designed bases, thus, might find applications in stabilizing a DNA and in the biophys. study thereof, if a pair of such donor acceptor C-nucleosides could be incorporated into a DNA sequence. After reading the article, we found that the author used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Synthetic Route of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineIn 2022 ,《Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides》 was published in RSC Chemical Biology. The article was written by Dysko, Anna; Baker, Ysobel R.; McClorey, Graham; Wood, Matthew J. A.; Fenner, Sabine; Williams, Glynn; El-Sagheer, Afaf; Brown, Tom. The article contains the following contents:

Oligonucleotides are rapidly emerging as powerful therapeutics for hard to treat diseases. Short single-stranded oligonucleotides can base pair with target RNA and alter gene expression, providing an attractive therapeutic approach at the genetic level. While conceptually appealing, oligonucleotides require chem. modification for clin. use. One emerging approach is to substitute the phosphodiester backbone with other chem. linkages such as triazole. The triazole linkage is inherently resistant to enzymic degradation, providing stability in vivo, and is uncharged, potentially improving cell-penetration and in vivo distribution. Triazole linkages, however, are known to reduce RNA target binding affinity. Here we show that by attaching pyrene or anthraquinone to the ribose sugar on the 5′-side of the triazole, it is possible to recover duplex stability and restore the splice switching ability of triazole-containing oligonucleotides. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis, distribution analysis and mechanism studies of N-acyl glucosamine-bearing oleanolic saponins》 was published in Bioorganic Chemistry in 2020. These research results belong to Juang, Yu-Pu; Lin, You-Yu; Chan, She-Hung; Chang, Chun-Kai; Shie, Jiun-Jie; Hsieh, Yves S. Y.; Guh, Jih-Hwa; Liang, Pi-Hui. Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The article mentions the following:

A series of N-acyl glucosamine-bearing triterpenoid saponins has been synthesized with cytotoxic activities evaluated against HL-60, PC-3, HCT-116, and CT-26 tumor cells. Saponins incorporated an oleanolic acid (OA) triterpenoidal core exhibited the highest cytotoxic activity. To study the influence of the lengths of acyl-carbon chain on N-position of glucosamine, cells were treated with 28-propargylamides and then reacted with an azido-fluorogenic probe under CuAAC click reactions to visualize the intact distributions of these compounds by confocal microscopy and flow cytometry; it was found that cytotoxic-active compounds (30-32) located in the cytosol and inactive compounds bearing longer carbon chains (33-35) were impenetrable across cell membranes. Our study demonstrated the defined lipophilic acyl-carbon chain length can precisely regulate the cytotoxic activity of saponins, which is useful for the future development of cytotoxic agents. Furthermore, using quant. proteomics and immuno-labeling, the mechanism of cytotoxicity induced by the synthetic saponin after membrane penetration could be a result of activation of death receptor pathway and inhibition of PI3K/Akt/mTOR pathway. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,ChemistrySelect included an article by Topchiy, Maxim A.; Ageshina, Alexandra A.; Chesnokov, Gleb A.; Sterligov, Grigorii K.; Rzhevskiy, Sergey A.; Gribanov, Pavel S.; Osipov, Sergey N.; Nechaev, Mikhail S.; Asachenko, Andrey F.. Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine. The article was titled 《Alkynyl- or Azido-Functionalized 1,2,3-Triazoles: Selective MonoCuAAC Promoted by Physical Factors》. The information in the text is summarized as follows:

In this present work, the possibility of selectivity control for mono addition in the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction of sym. diazides or diacetylenes in equimolar amounts based on phys. rather than chem. factors was proposed and investigated. Single cycloaddition in the CuAAC reaction of sym. diazides or diynes could be achieved by (a) precipitation of the monoaddn. product, from nonpolar solvent heptane and (b) the reaction halt after formation of monoaddn. product due to increase of the viscosity in solvent-free procedure. Thus, two new green one-step methods for the synthesis of alkynyl- or azido-functionalized 1,2,3-triazoles I [R = n-Pr, SiMe3, Ph, etc.; R1 = CH2CO2Et, Ph, Bn, etc.] were devised. By using these methods 17 compounds were obtained with good to excellent yields. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Journal of Controlled Release included an article by Shu, Yi; Yin, Hongran; Rajabi, Mehdi; Li, Hui; Vieweger, Mario; Guo, Sijin; Shu, Dan; Guo, Peixuan. Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine. The article was titled 《RNA-based micelles: A novel platform for paclitaxel loading and delivery》. The information in the text is summarized as follows:

RNA can serve as powerful building blocks for bottom-up fabrication of nanostructures for biotechnol. and biomedical applications. In addition to current self-assembly strategies utilizing base pairing, motif piling and tertiary interactions, we reported for the first time the formation of RNA based micellar nanoconstruct with a cholesterol mol. conjugated onto one helical end of a branched pRNA three-way junction (3WJ) motif. The resulting amphiphilic RNA micelles consist of a hydrophilic RNA head and a covalently linked hydrophobic lipid tail that can spontaneously assemble in aqueous solution via hydrophobic interaction. Taking advantage of pRNA 3WJ branched structure, the assembled RNA micelles are capable of escorting multiple functional modules. As a proof of concept for delivery for therapeutics, Paclitaxel was loaded into the RNA micelles with significantly improved water solubility The successful construction of the drug loaded RNA micelles was confirmed and characterized by agarose gel electrophoresis, at. force microscopy (AFM), dynamic light scattering (DLS), and fluorescence Nile Red encapsulation assay. The estimate critical micelle formation concentration ranges from 39 nM to 78 nM. The Paclitaxel loaded RNA micelles can internalize into cancer cells and inhibit their proliferation. Further studies showed that the Paclitaxel loaded RNA micelles induced cancer cell apoptosis in a Caspase-3 dependent manner but RNA micelles alone exhibited low cytotoxicity. Finally, the Paclitaxel loaded RNA micelles targeted to tumor in vivo without accumulation in healthy tissues and organs. There is also no or very low induction of pro-inflammatory response. Therefore, multivalence, cancer cell permeability, combined with controllable assembly, low or non toxic nature, and tumor targeting are all promising features that make our pRNA micelles a suitable platform for potential drug delivery. After reading the article, we found that the author used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

COA of Formula: C30H30N10In 2021 ,《Vitamin B12 Derivatives Suitably Tailored for the Synthesis of Photolabile Conjugates》 was published in Organic Letters. The article was written by Jackowska, Agnieszka; Gryko, Dorota. The article contains the following contents:

Vitamin B12 conjugates are broadly studied in biol. sciences. A method for the preparation of vitamin B12 conjugates that release tethered mols. upon exposure to light, is reported. Herein, we report vitamin B12 derivatives possessing a photolabile linker suitable for conjugation with amines, azides, and alkynes. The potential applications of such conjugates are broad and include the delivery of drugs, labels, and imaging agents to their place of action and spatiotemporal release. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8COA of Formula: C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.COA of Formula: C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Ramified derivatives of 5-(perylen-3-ylethynyl)uracil-1-acetic acid and their antiviral properties》 were Sapozhnikova, Ksenia A.; Slesarchuk, Nikita A.; Orlov, Alexey A.; Khvatov, Evgeny V.; Radchenko, Eugene V.; Chistov, Alexey A.; Ustinov, Alexey V.; Palyulin, Vladimir A.; Kozlovskaya, Liubov I.; Osolodkin, Dmitry I.; Korshun, Vladimir A.; Brylev, Vladimir A.. And the article was published in RSC Advances in 2019. Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The author mentioned the following in the article:

The propargylamide of N3-Pom-protected 5-(perylen-3-ylethynyl)uracil acetic acid, a universal precursor, was used in a CuAAC click reaction for the synthesis of several derivatives, including three ramified mols. with high activities against tick-borne encephalitis virus (TBEV). Pentaerythritol-based polyazides were used for the assembly of mols. containing 2…4 antiviral 5-(perylen-3-ylethynyl)uracil scaffolds, the first examples of polyvalent perylene antivirals. Cluster compounds showed enhanced absorbance, however, their fluorescence was reduced due to self-quenching. Due to the solubility issues, Pom group removal succeeded only for compounds with one peryleneethynyluracil unit. Four compounds, including one ramified cluster 9f, showed remarkable 13 nM EC50 values against TBEV in cell culture. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of C30H30N10In 2022 ,《Fluorinated click-derived tripodal ligands drive spin crossover in both iron(II) and cobalt(II) complexes》 appeared in Dalton Transactions. The author of the article were Noessler, Maite; Hunger, David; Neuman, Nicolas I.; Reimann, Marc; Reichert, Felix; Winkler, Mario; Klein, Johannes; Bens, Tobias; Suntrup, Lisa; Demeshko, Serhiy; Stubbe, Jessica; Kaupp, Martin; van Slageren, Joris; Sarkar, Biprajit. The article conveys some information:

Control of the spin state of metal complexes is important because it leads to a precise control over the phys. properties and the chem. reactivity of the metal complexes. Currently, controlling the spin state in metal complexes is challenging because a precise control of the properties of the secondary coordination sphere is often difficult. Noncovalent interactions in the secondary coordination sphere of transition metal complexes can enable spin state control. Here the authors exploit this strategy for fluorinated triazole ligands and present mononuclear CoII and FeII complexes with “”click””-derived tripodal ligands that contain mono-fluorinated benzyl substituents on the backbone. Structural characterization of 1 and 2 at 100 K revealed Co-N bond lengths that are typical of high spin (HS) CoII complexes. In contrast, the Fe-N bond lengths for 3 are characteristic of a low spin (LS) FeII state. All complexes show an intramol. face-to-face noncovalent interaction between two arms of the ligand. The influence of the substituents and of their geometric structure on the spin state of the metal center was studied through SQUID magnetometry, which revealed spin crossover occurring in compounds 1 and 3. EPR spectroscopy sheds further light on the electronic structures of 1 and 2 in their low- and high-spin states. Quantum-chem. calculations of the fluorobenzene mol. were performed to obtain insight into the influence of fluorine-specific interactions. The same fluorinated tripodal ligands induce SCO behavior in both FeII and CoII complexes. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Synthetic Route of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics