Category: 510758-28-8

Docker, Andrew; Bunchuay, Thanthapatra; Ahrens, Michael; Martinez-Martinez, Antonio J.; Beer, Paul D. published their research in Chemistry – A European Journal in 2021. The article was titled 《Chalcogen Bonding Ion-Pair Cryptand Host Discrimination of Potassium Halide Salts》.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The article contains the following contents:

A series of chalcogen, halogen and hydrogen bonding heteroditopic macrobicyclic cryptands are reported and their potassium halide ion-pair recognition properties investigated. Saliently, the co-bound potassium cation was determined to be crucial in switching on the bromide and iodide recognition properties of the resp. cryptand receptor. Importantly, the nature of the sigma-hole mediated interaction employed in the anion recognition component is demonstrated to significantly augment the ion-pair binding behavior, markedly so for the halogen bonding analog. Most notably the incorporation of a chelating chalcogen bonding donor motif significantly improves the selectivity towards KBr over KI, relative to halogen and hydrogen bonding analogs. In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

HPLC of Formula: 510758-28-8In 2019 ,《Self-assembled nanoparticles based on cyclodextrin-modified pullulan: Synthesis, and structural characterization using SAXS》 was published in Carbohydrate Polymers. The article was written by Stensgaard Diget, Jakob; Lund, Reidar; Nystrom, Bo; Wintgens, Veronique; Amiel, Catherine; Wimmer, Reinhard; Terndrup Nielsen, Thorbjoern. The article contains the following contents:

Synthesis of novel host-guest functionalized polymers is presented along with structural characterization using small-angle X-ray scattering (SAXS) of the resulting nanoparticles. Mono-6-deoxy-mono-6-azidoβCD (N3βCD) was grafted onto alkyne-functionalized pullulan via the “”click”” reaction copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) and an adamantane-modified dextran was prepared via the same strategy. Characterization of the polymers was carried out using NMR spectroscopy, gel filtration chromatog. (GFC), isothermal titration calorimetry (ITC) and SAXS. Nanoparticles were created via host-guest interactions between the well-defined βCD-pullulans and adamantane-modified dextran. Characterization was carried out using dynamic light scattering (DLS) and SAXS, which revealed spherical particles in the sub-100 nm range. The studies shed light on the importance of mol. structure and host-guest ratio on crucial properties such as particle size, size distribution, porosity and stability towards aggregation. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8HPLC of Formula: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.HPLC of Formula: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Efficient Conjugation to Phosphorothioate Oligonucleotides by Cu-Catalyzed Huisgen 1,3-Dipolar Cycloaddition》 were Honcharenko, Malgorzata; Honcharenko, Dmytro; Stroemberg, Roger. And the article was published in Bioconjugate Chemistry in 2019. SDS of cas: 510758-28-8 The author mentioned the following in the article:

Improving oligonucleotide delivery is critical for the further development of oligonucleotide-based therapeutics. Covalent attachment of reporter mols. is one of the most promising approaches toward efficient oligonucleotide-based therapies. An efficient methods for the attachment of a variety of reporter groups is Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition However, the majority of potential oligonucleotide (ON) therapeutics in clin. trials are carrying phosphorothioate (PS) linkages, and this robust conjugation method is not yet established for these ONs due to a general concern of Cu-S interaction. Here, we developed a method allowing for efficient conjugation of peptides to PS oligonucleotides. The method utilizes solid supported oligonucleotides that can be readily transformed into “”clickable ONs”” by simple linker conjugation and further reacted with an azido containing moiety (e.g., a peptide) using the CuBr × Me2S complex as a superior catalyst in that reaction. This study opens the way for further development of PS oligonucleotide-conjugates by means of efficient Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery》 were Marti Coma-Cros, Elisabet; Lancelot, Alexandre; San Anselmo, Maria; Neves Borgheti-Cardoso, Livia; Valle-Delgado, Juan Jose; Serrano, Jose Luis; Fernandez-Busquets, Xavier; Sierra, Teresa. And the article was published in Biomaterials Science in 2019. Recommanded Product: 510758-28-8 The author mentioned the following in the article:

Biomaterials for antimalarial drug transport still need to be investigated in order to attain nanocarriers that can tackle essential issues related to malaria treatment, e.g. complying with size requirements and targeting specificity for their entry into Plasmodium-infected red blood cells (pRBCs), and limiting premature drug elimination or drug resistance evolution. Two types of dendritic macromol. that can form vehicles suitable for antimalarial drug transport are herein explored. A new hybrid dendritic-linear-dendritic block copolymer based on Pluronic F127 and amino terminated 2,2′-bis(glycyloxymethyl)propionic acid dendrons with a poly(ester amide) skeleton (HDLDBC-bGMPA) and an amino terminated dendronized hyperbranched polymer with a polyester skeleton derived from 2,2′-bis(hydroxymethyl)propionic acid (DHP-bMPA) have provided self-assembled and unimol. micelles. It has also been observed that DHP-bMPA and HDLDBC-bGMPA incorporate into human umbilical vein endothelial cells with different subcellular localization, i.e. cytosolic and nuclear, resp. Drug loading capacity and encapsulation efficiencies for the antimalarial compounds chloroquine, primaquine and quinacrine ranging from 30% to 60% have been determined for both carriers. The resulting drug-loaded nanocarriers have been tested for their capacity to inhibit Plasmodium growth in in vitro and in vivo assays. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: 510758-28-8) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hadidi, Kaivin; Bellucci, Maria Cristina; Dall’Angelo, Sergio; Leeson-Payne, Alasdair; Rochford, Justin J.; Esko, Jeffery D.; Tor, Yitzhak; Volonterio, Alessandro published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Guanidinoneomycin-maleimide molecular transporter: synthesis, chemistry and cellular uptake》.Product Details of 510758-28-8 The article contains the following contents:

Guanidino-glycosides are a class of non-cytotoxic mol. transporters capable of delivering high mol. weight bioactive cargos into cells at low nanomolar concentrations Efficient bioconjugation with guanidinoglycosides has been previously demonstrated by utilizing a guanidinoneomycin decorated with a reactive but also unstable N-hydroxysuccinimmide ester-containing linker. Herein we report the synthesis, chem., and application of a new, stable guanidinoneomycin derivative armed with a highly specific maleimide moiety which allows for thiol-maleimide click chem., a highly popular bioconjugation strategy, widening the field of application of these intriguing and useful delivery vehicles. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《3D Printing of Supramolecular Polymers: Impact of Nanoparticles and Phase Separation on Printability》 was written by Rupp, Harald; Doehler, Diana; Hilgeroth, Philipp; Mahmood, Nasir; Beiner, Mario; Binder, Wolfgang H.. Category: triazolesThis research focused onthree dimensional printing supramol polymer nanoparticle; 3D printing; extrusion printing; melt rheology; supramolecular polymers. The article conveys some information:

3D printing of linear and three-arm star supramol. polymers with attached hydrogen bonds and their nanocomposites is reported. The concept is based on hydrogen-bonded supramol. polymers, known to form nano-sized micellar clusters. Printability is based on reversible thermal- and shear-induced dissociation of a supramol. polymer network, which generates stable and self-supported structures after printing, as checked via melt-rheol. and X-ray scattering. The linear and three-arm star poly(isobutylene)s PIB-B2 (Mn = 8500 g mol -1), PIB-B3 (Mn = 16 000 g mol -1), and linear poly(ethylene glycol)s PEG-B2 (Mn = 900 g mol-1, 8500 g mol -1) are prepared and then probed by melt-rheol. to adjust the viscosity to address the proper printing window. The supramol. PIB polymers show a rubber-like behavior and are able to form self-supported 3D printed objects at room temperature and below, reaching polymer strand diameters down to 200-300 μm. Nanocomposites of PIB-B2 with silica nanoparticles (12 nm, 5-15 wt%) are generated, in turn leading to an improvement of their shape persistence. A blend of the linear polymer PIB-B2 and the three-arm star polymer PIB-B3 (ratio ≈ 3/1 mol) reaches an even higher structural stability, able to build free-standing structures. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Category: triazoles) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 510758-28-8In 2020 ,《Alkynylated and Dendronized 5-Aza-7-deazaguanine Nucleosides: Cross-Coupling with Tripropargylamine and Linear Alkynes, Click Functionalization, and Fluorescence of Pyrene Adducts》 was published in Journal of Organic Chemistry. The article was written by Kondhare, Dasharath; Zhang, Aigui; Leonard, Peter; Seela, Frank. The article contains the following contents:

The change of the recognition face of 5-aza-7-deazaguanine bridgehead nucleosides with respect to purine nucleosides permits the construction of new purine-purine or purine-pyrimidine base pairs in DNA and RNA. Clickable derivatives of 5-aza-7-deazaguanine were synthesized by introducing ethynyl, 1,7-octadiynyl, and tripropargylamino side chains in the 7-position of the 5-aza-7-deazapurine moiety by Sonogashira cross-coupling. Click reactions were performed with 1-azidomethylpyrene by the copper-catalyzed azide-alkyne cycloaddition The copper(I)-catalyzed click reaction on the tripropargylamino nucleoside was significantly faster and higher yielding than that for nucleosides carrying linear alkynyl chains. Also, this reaction could be performed with copper(II) as the catalyst. An autocatalyzed cycle was suggested in which the click product acts as a catalyst. Pyrene click adducts of linear alkynylated nucleosides showed pyrene monomer emission, while tripropargylamino adducts showed monomer and excimer fluorescence. The fluorescence intensities of the 5-aza-7-deazaguanine nucleosides were higher than those of their 7-deazaguanine counterparts. The reported clickable nucleosides can be utilized to functionalize or to cross-link monomeric nucleosides or DNA for diagnostic or imaging purposes and other applications in nucleic acid chem. and biotechnol. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: 510758-28-8) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Imaging of chemotherapy-induced acute cardiotoxicity with 18F-labeled lipophilic cations》 were McCluskey, Stuart P.; Haslop, Anna; Coello, Christopher; Gunn, Roger N.; Tate, Edward W.; Southworth, Richard; Plisson, Christophe; Long, Nicholas J.; Wells, Lisa A.. And the article was published in Journal of Nuclear Medicine in 2019. Safety of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The author mentioned the following in the article:

Many chemotherapy agents are toxic to the heart, such that increasing numbers of cancer survivors are now living with the potentially lethal cardiovascular consequences of their treatment. Earlier and more sensitive detection of chemotherapy-induced cardiotoxicity may allow improved treatment strategies and increase long-term survival. Lipophilic cation PET tracers may be suitable for early detection of cardiotoxicity. This study aimed to evaluate an 18F-labeled lipophilic phosphonium cation, [1-(2-18F-fluoroethyl),1H[1,2,3]triazole-4-ethylene]triphenylphosphonium bromide (18F-MitoPhos), as a cardiac imaging agent, comparing it with leading PET and SPECT lipophilic cationic tracers before further assessing its potential for imaging cardiotoxicity in an acute doxorubicin model. Cardiac uptake and response to decreased mitochondrial membrane potential of 18F-MitoPhos and 99mTc-sestamibi were tested in isolated perfused rat hearts. Baseline pharmacokinetic profiles of 18F-MitoPhos and 18F-fluorobenzyltriphenylphosphonium and their response to acute doxorubicin-induced cardiotoxicity were assessed in rats in vivo (10, 15, or 20 mg of doxorubicin per kg, i.v., 48 h beforehand). Cardiac retention of 18F-MitoPhos was more than double that of 99mTc-sestamibi in isolated perfused rat hearts. A favorable biodistribution of 18F-MitoPhos in vivo was observed, with heart-to-tissue ratios of 304 ± 186, 11.2 ± 1.2, and 3.8 ± 0.6 for plasma, liver, and lung, resp. (60 min). A significant dose-dependent loss of cardiac retention of 18F-MitoPhos was observed on doxorubicin treatment, with average cardiac SUV from 30 to 60 min (mean ± SD) decreasing from 3.5 ± 0.5 (control) to 1.8 ± 0.1 (doxorubicin, 20 mg/kg). Other assessed biomarkers showed no alterations. 18F-MitoPhos showed pharmacokinetic parameters suitable for cardiac imaging. A significant dose response of cardiac uptake to doxorubicin treatment was observed before detectable biomarker alterations. 18F-MitoPhos is therefore a promising tracer for imaging chemotherapy-induced cardiotoxicity. To our knowledge, this is the first demonstration of radiolabeled lipophilic cations being used for the PET imaging of chemotherapy-induced cardiotoxicity and indicates the potential application of these compounds in this area. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Safety of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Safety of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Controlled Formation of Multilayer Films of Discrete Molecular Catalysts for the Oxygen Reduction Reaction Using a Layer-by-Layer Growth Mechanism Based on Sequential Click Chemistry》 was published in ACS Applied Energy Materials in 2020. These research results belong to Kallick, Jeremy D.; Feng, Wei-Jie; McCrory, Charles C. L.. HPLC of Formula: 510758-28-8 The article mentions the following:

Mol. electrocatalysts show promise for energy-relevant multielectron transformations due to their rationally tunable activity and selectivity from systematic ligand modifications. However, surface-immobilized mol. electrocatalytic systems are typically limited by low activity per geometric surface area compared to traditional solid-state analogs because of their lower active site surface coverage. Many existing methods for increasing surface coverage through the formation of multilayer films are based on radical-coupling or electropolymerization strategies that often result in dense, poorly defined films that may inhibit charge or substrate transport and complicate mechanistic studies. The authors report an alternative controlled layer-by-layer deposition strategy for the formation of multilayer catalyst films on C electrode surfaces based on sequential Cu(I)-catalyzed azide-alkyne cycloaddition reactions. As a proof of concept, the authors explore the growth of multilayer films of Cu(3,8-diethynylphenanthroline) for the O reduction reaction. Double-layer catalyst films operate with increased activity and selectivity for the reduction of O2 to H2O compared to single-layer catalyst films. The authors attribute this increased activity and selectivity to the increased coverage of the double-layer films which both increases the number of active sites and facilitates the 4e- reduction to H2O, rather than the 2e- reduction to H2O2. Unfortunately, growth of triple-layer catalyst films in this system was unsuccessful, possibly due to steric congestion in the double-layer films. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8HPLC of Formula: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.HPLC of Formula: 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Copper-Catalyzed Azide-Alkyne Cycloaddition of Hydrazoic Acid Formed In Situ from Sodium Azide Affords 4-Monosubstituted-1,2,3-Triazoles》 was written by Jankovic, Dominik; Virant, Miha; Gazvoda, Martin. Application of 510758-28-8This research focused ontriazole preparation green chem; azide alkyne cycloaddition copper. The article conveys some information:

Authors report a copper-catalyzed cycloaddition of hydrogen azide (hydrazoic acid, HN3) with terminal alkynes to form 4-substituted-1,2,3-triazoles in a sustainable manner. Hydrazoic acid was formed in situ from sodium azide under acidic conditions to react with terminal alkynes in a copper-catalyzed reaction. Using polydentate N-donor chelating ligands and mild organic acids, the reactions were realized to proceed at room temperature under aerobic conditions in a methanol-water mixture and with 5 mol % catalyst loadings to afford 4-substituted-1,2,3-triazoles in high yields. This method is amenable on a wide range of alkyne substrates, including unprotected peptides, showing diverse functional group tolerance. It is applicable for late-stage functionalization synthetic strategies, as demonstrated in the synthesis of the triazole analog of losartan. The preparation of orthogonally protected azahistidine from Fmoc-L-propargylglycine was realized on a gram scale. The hazardous nature of hydrazoic acid has been diminished as it forms in situ in <6% concentrations at which it is safe to handle. Reactions of distilled solutions of hydrazoic acid indicated its role as a reactive species in the copper-catalyzed reaction. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics