Yu, Ping’s team published research in Nucleosides, Nucleotides & Nucleic Acids in 2021 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

《Fluorescent labeling of s2T-incorporated DNA and m5s2U-modified RNA》 was written by Yu, Ping; Zhou, Honglin; Li, Yuanyuan; Du, Zhifeng; Wang, Rui. SDS of cas: 510758-28-8This research focused ontranslation transcription RNA DNA duplex preparation fluorescent labeling nucleotide; Sulfur modification; alkylation; m5s2U; s2T; sulfur exchange. The article conveys some information:

We report herein comprehensive investigations of alkylation/sulfur exchange reactions of sulfur-containing substrates including nucleosides such as s2U, m5s2U, s4U, s2A and s2T-incorporated DNA enable by comprehensive screenings of the reagents (). It has been proven that iodoacetamide () displays the most promising feasibility toward sulfur-containing substrates including s2T, s2U, m5s2U, s4U and s2A. In sharp contrast, the alkylation process with S-benzyl methanethiosulfonate (BMTS) displays the best application potential only for s4U. Based on these results, the fluorescent labeling of s2T-incorporated DNA and m5s2U-modified RNA has been achieved. Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.1942044. After reading the article, we found that the author used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Danielsen, Mathias B.’s team published research in Chemistry – A European Journal in 2021 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Danielsen, Mathias B.; Christensen, Niels Johan; Joergensen, Per T.; Jensen, Knud J.; Wengel, Jesper; Lou, Chenguang published an article in 2021. The article was titled 《Polyamine-Functionalized 2′-Amino-LNA in Oligonucleotides: Facile Synthesis of New Monomers and High-Affinity Binding towards ssDNA and dsDNA》, and you may find the article in Chemistry – A European Journal.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

Attachment of cationic moieties to oligonucleotides (ONs) promises not only to increase the binding affinity of antisense ONs by reducing charge repulsion between the two neg. charged strands of a duplex, but also to augment their in vivo stability against nucleases. In this study, polyamine functionality was introduced into ONs by means of 2′-amino-LNA scaffolds. The resulting ONs exhibited efficient binding towards ssDNA, ssRNA and dsDNA targets, and the 2′-amino-LNA analog carrying a tri-aminated linker showed the most pronounced duplex- and triplex-stabilizing effect. Mol. modeling revealed that favorable conformational and electrostatic effects led to salt-bridge formation between pos. charged polyamine moieties and the Watson-Hoogsteen groove of the dsDNA targets, resulting in the observed triplex stabilization. All the investigated monomers showed increased resistance against 3′-nucleolytic digestion relative to the non-functionalized controls. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Steinmeyer, Jeannine’s team published research in Organic & Biomolecular Chemistry in 2018 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

In 2018,Steinmeyer, Jeannine; Walter, Heidi-Kristin; Bichelberger, Mathilde A.; Schneider, Violetta; Kubar, Tomas; Roenicke, Franziska; Olshausen, Bettina; Nienhaus, Karin; Nienhaus, Gerd Ulrich; Schepers, Ute; Elstner, Marcus; Wagenknecht, Hans-Achim published 《””siRNA traffic lights””: arabino-configured 2′-anchors for fluorescent dyes are key for dual color readout in cell imaging》.Organic & Biomolecular Chemistry published the findings.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

Two fluorescent dyes covalently attached in diagonal interstrand orientation to siRNA undergo energy transfer and thereby enable a dual color fluorescence readout (red/green) for hybridization. Three different structural variations were carried out and compared by their optical properties, including (i) the base surrogate approach with an acyclic linker as a substitute of the 2-deoxyriboside between the phosphodiester bridges, (ii) the 2′-modification of conventional ribofuranosides and (iii) the arabino-configured 2′-modification. The double stranded siRNA with the latter type of modification delivered the best energy transfer efficiency, which was explained by mol. dynamics simulations that showed that the two dyes are more flexible at the arabino-configured sugars compared to the completely stacked situation at the ribo-configured ones. Single mol. fluorescence lifetime measurements indicate their application in fluorescence cell imaging, which reveals a red/green fluorescence contrast in particular for the arabino-configured 2′-modification by the two dyes, which is key for tracking of siRNA transport into HeLa cells. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Bojtar, Marton’s team published research in Beilstein Journal of Organic Chemistry in 2018 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

In 2018,Bojtar, Marton; Janzso-Berend, Peter Zoltan; Mester, David; Hessz, Dora; Kallay, Mihaly; Kubinyi, Miklos; Bitter, Istvan published 《An uracil-linked hydroxyflavone probe for the recognition of ATP》.Beilstein Journal of Organic Chemistry published the findings.Synthetic Route of C30H30N10 The information in the text is summarized as follows:

Nucleotides are essential mols. in living systems due to their paramount importance in various physiol. processes. In the past years, numerous attempts were made to selectively recognize and detect these analytes, especially ATP using small-mol. fluorescent chemosensors. Despite the various solutions, the selective detection of ATP is still challenging due to the structural similarity of various nucleotides. In this paper, we report the conjugation of a uracil nucleobase to the known 4′-dimethylamino-hydroxyflavone fluorophore. The complexation of this scaffold with ATP is already known. The complex is held together by stacking and electrostatic interactions. To achieve multi-point recognition, we designed the uracil-appended version of this probe to include complementary base-pairing interactions. The theor. calculations revealed the availability of multiple complex structures. The synthesis was performed using click chem. and the nucleotide recognition properties of the probe were evaluated using fluorescence spectroscopy. The first, uracil-containing fluorescent ATP probe based on a hydroxyflavone fluorophore was synthesized and evaluated. A selective complexation with ATP was observed and a ratiometric response in the excitation spectrum. In the experiment, the researchers used many compounds, for example, Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Synthetic Route of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kitamura, Kai’s team published research in Journal of the American Chemical Society in 2018 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

In 2018,Kitamura, Kai; Itoh, Hiroaki; Sakurai, Kaori; Dan, Shingo; Inoue, Masayuki published 《Target Identification of Yaku’amide B and Its Two Distinct Activities against Mitochondrial FoF1-ATP Synthase》.Journal of the American Chemical Society published the findings.SDS of cas: 510758-28-8 The information in the text is summarized as follows:

Yaku’amide B (1b) is a structurally unique tetradecapeptide bearing four b,b-dialkylated a,b-unsaturated amino acid residues. Growth-inhibitory profile of 1b against a panel of 39 human cancer cell lines is distinct from those of clin. used anticancer drugs, suggesting a novel mechanism of action. We achieved total syntheses of chem. probes based on 1b and elucidated the cellular target and mode of action of 1b. Fluorescent (3, 4) and biotinylated (5, 6) derivatives of 1b were prepared for cell imaging studies and pull-down assays, resp. In addition, the unnatural enantiomer of 1b (ent-1b) and its fluorescent probe (ent-3) were synthesized for control experiments Subcellular localization anal. using 3 and 4 showed that 1b selectively accumulates in the mitochondria of MCF-7 human breast cancer cells. Pull-down assays with 6 revealed FoF1-ATP synthase as the major target protein of 1b. Consistent with these findings, biochem. activity assays showed that 1b inhibits ATP production catalyzed by mitochondrial FoF1-ATP synthase. Remarkably, 1b was also found capable of enhancing the ATP hydrolytic activity of FoF1-ATP synthase. On the other hand, ent-1b inhibits ATP synthesis more weakly than 1b, and does not affect ATP hydrolysis, suggesting the stereospecific requirement for the characteristic multimodal functions of 1b. These findings corroborate that 1b causes growth arrest in MCF-7 cells by inhibiting ATP production and enhancing ATP hydrolysis, thereby depleting the cellular ATP pool. This study provides, for the first time, a structural basis for the design and development of anticancer agents exploiting the novel mode of action of 1b. After reading the article, we found that the author used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8SDS of cas: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.SDS of cas: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Sun, Xiaolong’s team published research in Journal of the American Chemical Society in 2020 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

《Chemically Triggered Synthesis, Remodeling, and Degradation of Soft Materials》 was published in Journal of the American Chemical Society in 2020. These research results belong to Sun, Xiaolong; Chwatko, Malgorzata; Lee, Doo-Hee; Bachman, James L.; Reuther, James F.; Lynd, Nathaniel A.; Anslyn, Eric V.. Application of 510758-28-8 The article mentions the following:

Polymer topol. dictates dynamic and mech. properties of materials. For most polymers, topol. is a static characteristic. In this article, we present a strategy to chem. trigger dynamic topol. changes in polymers in response to a specific chem. stimulus. Starting with a dimerized PEG and hydrophobic linear materials, a lightly crosslinked polymer, and a crosslinked hydrogel, transformations into an amphiphilic linear polymer, lightly crosslinked and linear random copolymers, a crosslinked polymer, and three different hydrogel matrixes were achieved via two controllable crosslinking reactions: reversible conjugate additions and thiol-disulfide exchange. Significantly, all the polymers, before or after topol. changes, can be triggered to degrade into thiol- or amine-terminated small mols. The controllable transformations of polymeric morphologies and their degradation herald a new generation of smart materials. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Sapotta, Meike’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8

The author of 《A Water-Soluble Perylene Bisimide Cyclophane as a Molecular Probe for the Recognition of Aromatic Alkaloids》 were Sapotta, Meike; Hofmann, Anja; Bialas, David; Wuerthner, Frank. And the article was published in Angewandte Chemie, International Edition in 2019. Product Details of 510758-28-8 The author mentioned the following in the article:

Herein, we report a water-soluble macrocyclic host based on perylene bisimide (PBI) chromophores that recognizes natural aromatic alkaloids in aqueous media by intercalating them into its hydrophobic cavity. The host-guest binding properties of our newly designed receptor with several alkaloids were studied by UV/Vis and fluorescence titration experiments as the optical properties of the chromophoric host change significantly upon complexation of guests. Structural information on the host-guest complexes was obtained by 1D and 2D NMR spectroscopy and mol. modeling. Our studies reveal a structure-binding property relationship for a series of structurally diverse aromatic alkaloids with the new receptor and higher binding affinity for the class of harmala alkaloids. To our knowledge, this is the first example of a chromophoric macrocyclic host employed as a mol. probe for the recognition of aromatic alkaloids. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wagner, Nicolai’s team published research in Angewandte Chemie, International Edition in 2018 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Electric Literature of C30H30N10

In 2018,Angewandte Chemie, International Edition included an article by Wagner, Nicolai; Stephan, Milena; Hoeglinger, Doris; Nadler, Andre. Electric Literature of C30H30N10. The article was titled 《A Click Cage: Organelle-Specific Uncaging of Lipid Messengers》. The information in the text is summarized as follows:

Lipid messengers exert their function on short time scales at distinct subcellular locations, yet most exptl. approaches for perturbing their levels trigger cell-wide concentration changes. Herein, we report on a coumarin-based photocaging group that can be modified with organelle-targeting moieties by click chem. and thus enables photorelease of lipid messengers in distinct organelles. We show that caged arachidonic acid and sphingosine derivatives can be selectively delivered to mitochondria, the ER, lysosomes, and the plasma membrane. By comparing the cellular calcium transients induced by localized uncaging of arachidonic acid and sphingosine, we show that the precise intracellular localization of the released second messenger is crucial for the signaling outcome. Ultimately, we anticipate that this new class of caged compounds will greatly facilitate the study of cellular processes on the organelle level. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Electric Literature of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Electric Literature of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Leigh, David A.’s team published research in Journal of the American Chemical Society in 2019 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8

Product Details of 510758-28-8In 2019 ,《Stereoselective Synthesis of Molecular Square and Granny Knots》 was published in Journal of the American Chemical Society. The article was written by Leigh, David A.; Pirvu, Lucian; Schaufelberger, Fredrik. The article contains the following contents:

The authors report on the stereoselective synthesis of both mol. granny and square knots through the use of lanthanide-complexed overhand knots of specific handedness as three-crossing “”entanglement synthons””. The composite knots are assembled by combining two entanglement synthons (of the same chirality for a granny knot; of opposite handedness for a square knot) in three synthetic steps: first, a CuAAC reaction joins together one end of each overhand knot. Ring-closing olefin metathesis (RCM) then affords the closed-loop knot, locking the topol. This allows the lanthanide ions necessary for stabilizing the entangled conformation of the synthons to subsequently be removed. The composite knots were characterized by 1H and 13C NMR spectroscopy and mass spectrometry and the chirality of the knot stereoisomers compared by CD. The synthetic strategy of combining building blocks of defined stereochem. (here overhand knots of Λ- or Δ-handed entanglement) is reminiscent of the chiron approach of using minimalist chiral synthons in the stereoselective synthesis of mols. with multiple asym. centers. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tan, Min’s team published research in Macromolecules (Washington, DC, United States) in 2022 | CAS: 510758-28-8

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8

In 2022,Tan, Min; Wang, Xiaoying; Xie, Tong; Zhang, Zhen; Shi, Yi; Li, Yuanchao; Chen, Yongming published an article in Macromolecules (Washington, DC, United States). The title of the article was 《Fluorogenic Mechanophore Based on Dithiomaleimide with Dual Responsiveness》.Related Products of 510758-28-8 The author mentioned the following in the article:

The maleimide scaffold is widely used for the preparation of fluorogenic probes owing to its good fluorescence quenching ability. Here, we demonstrate that it can be also employed to prepare fluorogenic mechanophores. A dithiomaleimide-based mechanophore with two dansyl fluorophores attached to the maleimide core via the thioether bond is synthesized and incorporated into polymer chains. Upon mechanochem. activation, the relatively weak C-S is cleaved hypothetically due to its low bond dissociation energy, resulting in the removal of the maleimide conjugation and turning on of the dansyl fluorophore with >5-fold increase in the fluorescence emission peak intensity at 510 nm. In addition, an excess of a thiol can also lead to the cleavage of the dansyl fluorophore from the maleimide via thiol-exchange reactions. This mechanophore with dual responsiveness may have potential applications in stress sensing as well as thiol sensing. Moreover, the design concept of the mechanophore may allow access to many other fluorogenic mechanophores, since a number of fluorophores covering a wide range of emission wavelengths have been reported to be quenched by maleimides. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics