Finzi, Paola Vita et al. published their research in Chimica e l’Industria (Milan, Italy) in 1965 |CAS: 5301-96-2

The Article related to , azides, sulfonyl azides role: uses (uses), ir spectra, nmr (nuclear magnetic resonance), sulfonyl compounds, sulfonyl azides and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

Finzi, Paola Vita published an article in 1965, the title of the article was Reactions between sulfone azides and arylacetylenes.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

cf. CA 60, 5479g; 62, 13078d. Sulfone azides react with PhCCH (I) and some p-substituted phenylacetylenes yielding the corresponding 5-phenyltriazole sulfonates instead of the 1-sulfonyl-5-phenyltriazole monohydrates (Boyer, et al., CA 53, 15065e). Equimol. amounts are boiled for 12-16-hrs. to give low yields (2-30%) of pure crystalline products. PhSO2N3 (II), p-MeC6H4SO2N3 (III), p-BrC6H4SO2N3(IV), and MeSO2N3 (V) react with I to yield 5-phenyltriazole benzenesulfonate (m. 164-5°), tosylate(m. 170-1°), p-bromobenzenesulfonate (m. 160-1°), and methanesulfonate (m. 143.5-4.5°), resp. By a similar process III reacts with p-BrC6H4CCH, with p-ClC6H4CCH, and with β-C10H7CCH to yield the corresponding tosylates, m. 185-6.5°, 182.5-3.5°, and 174-5.5°, resp. As a confirmation of the proposed structure the corresponding 4-phenyltriazoles were treated in the cold with p-MeC6H4SO3H in iso-Pr2O and the same results as above were obtained except in the case of II with p-MeC6H4CCH, of II with p-MeOC6H4CCH, and of III with V where 5-tolyl-1-tosyl-1,2,3-triazole (m. 161-2°), 5-(p-methoxyphenyl)-1-tosyl-1,2,3-triazole (m. 133.5-4.5°), and 5-phenyl-1-(p-bromophenylsulfonyl)-1,2,3-triazole (m. 132.5-33°), were obtained, resp. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to , azides, sulfonyl azides role: uses (uses), ir spectra, nmr (nuclear magnetic resonance), sulfonyl compounds, sulfonyl azides and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Rohrig, Ute F. et al. published their research in Journal of Medicinal Chemistry in 2012 |CAS: 5301-96-2

The Article related to aryl triazole preparation indoleamine dioxygenase inhibition sar, Pharmacology: Structure-Activity and other aspects.Application of 5301-96-2

On June 14, 2012, Rohrig, Ute F.; Majjigapu, Somi Reddy; Grosdidier, Aurelien; Bron, Sylvian; Stroobant, Vincent; Pilotte, Luc; Colau, Didier; Vogel, Pierre; Van den Eynde, Benoit J.; Zoete, Vincent; Michielin, Olivier published an article.Application of 5301-96-2 The title of the article was Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition. And the article contained the following:

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target for the treatment of diseases such as cancer that involve pathol. immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low mol. weight inhibitors, the most active being of nanomolar potency both in an enzymic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quant. structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chem. derived charges of the triazole ring demonstrated a good explanatory power for the observed activities. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application of 5301-96-2

The Article related to aryl triazole preparation indoleamine dioxygenase inhibition sar, Pharmacology: Structure-Activity and other aspects.Application of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Kallander, Lara S. et al. published their research in Journal of Medicinal Chemistry in 2005 |CAS: 5301-96-2

The Article related to aryltriazole derivative preparation methionine aminopeptidase inhibitor angiogenesis, Pharmacology: Structure-Activity and other aspects.Category: triazoles

On September 8, 2005, Kallander, Lara S.; Lu, Qing; Chen, Wenfang; Tomaszek, Thaddeus; Yang, Guang; Tew, David; Meek, Thomas D.; Hofmann, Glenn A.; Schulz-Pritchard, Christina K.; Smith, Ward W.; Janson, Cheryl A.; Ryan, M. Dominic; Zhang, Gui-Feng; Johanson, Kyung O.; Kirkpatrick, Robert B.; Ho, Thau F.; Fisher, Paul W.; Mattern, Michael R.; Johnson, Randall K.; Hansbury, Michael J.; Winkler, James D.; Ward, Keith W.; Veber, Daniel F.; Thompson, Scott K. published an article.Category: triazoles The title of the article was 4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo. And the article contained the following:

Inhibitors of human methionine aminopeptidase type 2 (hMetAP2) are of interest as potential treatments for cancer. A new class of small mol. reversible inhibitors of hMetAP2 was discovered and optimized, the 4-aryl-1,2,3-triazoles. Compound (I), a potent inhibitor of cobalt-activated hMetAP2, also inhibits human and mouse endothelial cell growth. Using a mouse matrigel model, this reversible hMetAP2 inhibitor was also shown to inhibit angiogenesis in vivo. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Category: triazoles

The Article related to aryltriazole derivative preparation methionine aminopeptidase inhibitor angiogenesis, Pharmacology: Structure-Activity and other aspects.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Huang, Qiang et al. published their research in European Journal of Medicinal Chemistry in 2011 |CAS: 5301-96-2

The Article related to structure preparation aryl triazole derivative indoleamine dioxygenase inhibitor cancer, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 5301-96-2

Huang, Qiang; Zheng, Maofa; Yang, Shuangshuang; Kuang, Chunxiang; Yu, Cunjing; Yang, Qing published an article in 2011, the title of the article was Structure-activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors.HPLC of Formula: 5301-96-2 And the article contains the following content:

Previously, we have reported the design and synthesis of 4-aryl-1H-1,2,3-triazoles as inhibitors of indoleamine 2,3-dioxygenase (IDO), a promising therapeutic target of cancer. Here, we present the structure-activity relationship and enzyme kinetic studies on a series of 4-aryl-1H-1,2,3-triazoles. Three compounds (1, 6, 8) were found to possess more IDO inhibitory potency than the most commonly used 1-methyltryptophan. The results from the structure-activity relationship and mol. docking studies indicated that an electron-withdrawing group with low steric hindrance near the NH group of triazoles was necessary for the IDO inhibition. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to structure preparation aryl triazole derivative indoleamine dioxygenase inhibitor cancer, Pharmacology: Structure-Activity and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lee, Dong-Hwan et al. published their research in Current Pharmaceutical Design in 2018 |CAS: 5301-96-2

The Article related to glycoprotein inhibitor anticancer agent colon adenocarcinoma, artemisinin, immunoblotting techniques, p-glycoprotein, paclitaxel, rifampin, triazolyl artemisinin., Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 5301-96-2

On December 31, 2018, Lee, Dong-Hwan; Hasanuzzaman, M.; Kwon, Daeho; Choi, Hye-Young; Kim, So Myoung; Kim, Dong Jin; Kang, Dong Ju; Hwang, Tae-Ho; Kim, Hyung-Hoi; Shin, Ho Jung; Shin, Jae-Gook; Oh, Sangtae; Lee, Seokjoon; Kim, So Won published an article.Recommanded Product: 5301-96-2 The title of the article was 10-Phenyltriazoyl Artemisinin is a Novel P-glycoprotein Inhibitor that Suppresses the Overexpression and Function of P-glycoprotein. And the article contained the following:

The effect of drugs on ATP-binding cassette transporters, especially permeability-glycoprotein (P-gp), is an important consideration during new anti-cancer drug development. In this context, the effects of a newly synthesized artemisinin derivative, 10-(4-phenyl-1H-1,2,3- triazol)-artemisinin (5a), were evaluated on P-gp expression and function. Reverse transcript polymerase chain reaction and immunoblotting techniques were used to determine the effect of 5a on P-gp expression in LS174T cells. In addition, the ability of 5a to work as either a substrate or an inhibitor of P-gp was investigated through different methods. The results revealed that 5a acts as a novel P-gp inhibitor that dually suppresses the overexpression and function of P-glycoprotein. Co-treatment of LS174T cell line, human colon adenocarcinoma cell line, with 5a and paclitaxel recovered the anticancer effect of paclitaxel by controlling the acquired drug resistance pathway. The overexpression of P-gp induced by rifampin and paclitaxel in a colorectal cell line was suppressed by 5a which could be a novel inhibitory substrate inhibiting the transport of paclitaxel by P-gp. The results revealed that 5a can be classified as a type B P-gp inhibitor (with both substrate and inhibitor activities) with an addnl. function of suppressing P-gp overexpression. The results might be clin. useful in the development of anticancer drugs against cancers with multidrug resistance. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 5301-96-2

The Article related to glycoprotein inhibitor anticancer agent colon adenocarcinoma, artemisinin, immunoblotting techniques, p-glycoprotein, paclitaxel, rifampin, triazolyl artemisinin., Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Tome, A. C. et al. published their research in Science of Synthesis in 2004 |CAS: 5301-96-2

The Article related to review triazole preparation cyclization aromatization ring transformation, Heterocyclic Compounds (More Than One Hetero Atom): Reviews and other aspects.Computed Properties of 5301-96-2

Tome, A. C. published an article in 2004, the title of the article was Product class 13: 1,2,3-triazoles.Computed Properties of 5301-96-2 And the article contains the following content:

A review. Methods to prepare 1,2,3-triazoles are reviewed including cyclization, aromatization, ring transformation and substituent modification. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2

The Article related to review triazole preparation cyclization aromatization ring transformation, Heterocyclic Compounds (More Than One Hetero Atom): Reviews and other aspects.Computed Properties of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Ge, Jhih Kuei et al. published their patent in 2019 |CAS: 5301-96-2

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Related Products of 5301-96-2

On April 4, 2019, Ge, Jhih Kuei; Lee, Yi-Chia; Liu, Wen Dar; Kuo, Chi-Hsien published a patent.Related Products of 5301-96-2 The title of the patent was Stripper solutions and methods of using stripper solutions. And the patent contained the following:

The invention relates to a stripper solution for removing a resist from a substrate, comprising one or more than one organic solvent, water, hydroxylamine or one or more than one derivative of hydroxylamine, one or more than one corrosion inhibitor, optional one or more than one surfactant, and one or more than one quaternary ammonium hydroxide, wherein the quaternary ammonium hydroxide has the formula: R2-N(R1)(R3)-R4, wherein R1, R2, R3, and R4 are alkyl groups, benzyl, aryl groups, or a combination thereof having collectively at least 5 carbons. The invention also relates to a method for removing a resist from a substrate, comprising; (a) providing a substrate having a resist thereon; (b) contacting the substrate with a stripper solution for a time sufficient to remove the resist; (c) removing the substrate from the stripping solution; and {d} rinsing the stripper solution from the substrate with a solvent. An electronic device prepared according to the inventive method is also claimed. The invention also claims a method for preparing a stripper solution, comprising: (a) providing a container; (b) providing components of the stripper solution composition; and (c) adding components of stripper solution to container to provide contents. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Related Products of 5301-96-2

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Related Products of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Ge, Jhih Kuei et al. published their patent in 2019 |CAS: 5301-96-2

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.COA of Formula: C9H9N3

On April 4, 2019, Ge, Jhih Kuei; Lee, Yi-Chia; Liu, Wen Dar; Kuo, Chi-Hsien published a patent.COA of Formula: C9H9N3 The title of the patent was Stripper solutions and methods of using stripper solutions. And the patent contained the following:

The invention relates to a stripper solution for removing a resist from a substrate, comprising one or more than one organic solvent, water, hydroxylamine or one or more than one derivative of hydroxylamine, one or more than one corrosion inhibitor, optional one or more than one surfactant, and one or more than one quaternary ammonium hydroxide, wherein the quaternary ammonium hydroxide has the formula: R2-N(R1)(R3)-R4, wherein R1, R2, R3, and R4 are alkyl groups, benzyl, aryl groups, or a combination thereof having collectively at least 5 carbons. The invention also relates to a method for removing a resist from a substrate, comprising; (a) providing a substrate having a resist thereon; (b) contacting the substrate with a stripper solution for a time sufficient to remove the resist; (c) removing the substrate from the stripping solution; and {d} rinsing the stripper solution from the substrate with a solvent. An electronic device prepared according to the inventive method is also claimed. The invention also claims a method for preparing a stripper solution, comprising: (a) providing a container; (b) providing components of the stripper solution composition; and (c) adding components of stripper solution to container to provide contents. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).COA of Formula: C9H9N3

The Article related to cleaning composition stripper photoresist removal electronic device fabrication, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.COA of Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yang, Yong-Zheng et al. published their research in Organic Letters in 2019 |CAS: 5301-96-2

The Article related to xanthenazole preparation electrochem cross coupling xanthene azole, intermol anodic oxidative cross dehydrogenative coupling, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.HPLC of Formula: 5301-96-2

On May 3, 2019, Yang, Yong-Zheng; Song, Ren-Jie; Li, Jin-Heng published an article.HPLC of Formula: 5301-96-2 The title of the article was Intermolecular Anodic Oxidative Cross-Dehydrogenative C(sp3)-N Bond-Coupling Reactions of Xanthenes with Azoles. And the article contained the following:

A new anode strategy for accessing xanthen-9-azoles via an electrochem. C(sp3)-H/N-H cross-coupling of xanthenes with azoles is described. This reaction proceeds efficiently with a broad scope of both xanthenes and N-H-free azoles under metal- and addnl. oxidant-free conditions and represents a new access to direct incorporation of important N-heterocycle units into the resulting xanthenes. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to xanthenazole preparation electrochem cross coupling xanthene azole, intermol anodic oxidative cross dehydrogenative coupling, Heterocyclic Compounds (More Than One Hetero Atom): General and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Bolkan, Steven A. et al. published their patent in 1998 |CAS: 5301-96-2

The Article related to aqueous cleaning composition corrosion inhibitor, borate alkali triazole corrosion inhibitor, mild alk aqueous cleaner copper, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Synthetic Route of 5301-96-2

On April 7, 1998, Bolkan, Steven A.; Dunn, Steve published a patent.Synthetic Route of 5301-96-2 The title of the patent was Aqueous metal cleaner having an anticorrosion system. And the patent contained the following:

The title composition is composed of an alk. metal salt, a surfactant, and a corrosion inhibitor with a pH ∼7.5 to <10, preferably silicate free, of a combination of a triazole compound and an alkali metal borate. The use of 1,2,3-benzotriazole (Cobratec) and borax prevent discoloration of steel in addition to providing an anticorrosive effect at mild pH levels. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to aqueous cleaning composition corrosion inhibitor, borate alkali triazole corrosion inhibitor, mild alk aqueous cleaner copper, Surface Active Agents and Detergents: Cleaning Compositions and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics