Category: 5301-96-2

Wan, Zhaohua; Wang, Dan; Yang, Zixuan; Zhang, Heng; Wang, Shengchun; Lei, Aiwen published an article in 2020, the title of the article was Electrochemical oxidative C(sp3)-H azolation of lactams under mild conditions.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

An electrochem. oxidative direct C(sp3)-H azolation of lactams was reported under metal catalyst-free and external chem. oxidant-free conditions. This electrochem. C(sp3)-H/N-H coupling was characterized by its broad substrate scope of azoles and lactams under mild conditions at room temperature Mechanistic studies suggested that the reaction possibly involves a radical process. Moreover, the site selectivity was explained by DFT calculations More meaningfully, a gram-scale synthesis method of flow electrochem. was employed to show the scaled-up applicability of this transformation. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to azole lactam electrochem oxidative azolation, azolyl lactam preparation, amide azole electrochem oxidative azolation, amido azole preparation, pyrazole urea electrochem oxidative azolation, pyrazolyl urea preparation and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 30, 2022, Sandeep, K.; Sanjeeva Kumar, A.; Qureshi, Asif Ali; Kumara Swamy, K. C. published an article.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was (3+2) Cycloadditions of Vinyl Sulfonyl Fluorides with Ethyl Diazoacetate or Azides: Metal-Free Synthesis of Pyrazole and Triazole Scaffolds via SO2 Elimination. And the article contained the following:

A (3 +2) cycloaddition reaction between substituted vinyl sulfonyl fluorides RCH=CHS(O)2F (R = Ph, 2,4,6-trimethylphenyl, naphthalen-2-yl, etc.) and 3,4-dihydronaphthalene-2-sulfonyl fluoride and Et diazoacetate or azides R1N3 (R1 = Ph, Bn, 4-nitrophenyl, etc.) for the rapid construction of pyrazole I or triazole cores II (R1 = H, Ph, Bn, 4-nitrophenyl, etc.) via Michael addition and SO2 gas elimination is developed. Trimethylsilyl azide or organic azide selectively attacks at the β-carbon of vinyl sulfonyl fluoride rather than at the S(VI) center and generates C-substituted or C,N-disubstituted triazole II. In contrast, vinyl sulfonyl fluorides react with Et diazoacetate to generate pyrazoles I in good to high yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to pyrazole preparation chemoselective, ethyl diazoacetate vinyl sulfonyl fluoride cycloaddition michael addition, triazole preparation chemoselective, azide vinyl sulfonyl fluoride cycloaddition michael addition and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Oliva, Cristina G.; Jagerovic, Nadine; Goya, Pilar; Alkorta, Ibon; Elguero, Jose; Cuberes, Rosa; Dordal, Alberto published an article in 2010, the title of the article was N-substituted-1,2,3-triazoles: synthesis, characterization and evaluation as cannabinoid ligands.Synthetic Route of 5301-96-2 And the article contains the following content:

A series of new N1-, N2- and N3-substituted 1,2,3-triazole derivatives has been synthesized by cycloaddition of butyltin azide with substituted alkynes followed by N-alkylation reactions. The regioisomers have been isolated and characterized using NMR techniques. GIAO/B3LYP calculations of the absolute shieldings have been performed to verify the assignments and so the structures have been unequivocally identified. The proportion in which the three isomers are obtained corresponds with the relative order of stability indicated by the energy values calculated at the B3LYP level. CB1 cannabinoid receptor binding assays have been performed but none of the compounds showed significant activity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to tributyltin azide alkyne cycloaddition alkyl bromide alkylation, triazole nitrogen alkyl derivative regioselective preparation calculated chem shift, cannabinoid receptor binding assay alkyl triazole inactive and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 18, 2017, Cha, Hyojin; Lee, Kyongkyu; Chi, Dae Yoon published an article.Electric Literature of 5301-96-2 The title of the article was Synthesis of N-unsubstituted 1,2,3-triazoles via aerobic oxidative N-dealkylation using copper(II) acetate. And the article contained the following:

A copper-catalyzed aerobic oxidative C-N bond cleavage reaction was developed for the synthesis of 4-substituted-NH-1,2,3-triazoles. Diverse β-ketotriazoles derivatives, which are the starting materials for the aerobic oxidative C-N bond cleavage reaction, were prepared from nine aryl and seven alkyl alkynes and α-azidoacetophenone by a copper(I)-catalyzed [3 + 2] cycloaddition reaction. The aerobic oxidation of α-(1,2,3-triazol-1-yl)acetophenones using a catalytic amount of copper(II) acetate in the presence oxygen under neutral conditions gave the title compounds in high yield [e.g., 1-phenacyl-4-phenyl-1H-1,2,3-triazole → 4-phenyl-1H-1,2,3-triazole (91%) in presence of Cu(OAc)2 and pyridine in PhCF3 under O2]. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Electric Literature of 5301-96-2

The Article related to copper catalyzed oxidative carbon nitrogen bond cleavage triazolylacetophenone, aerobic oxidative dealkylation triazolylacetophenone, triazole synthesis, azidoacetophenone cycloaddition aryl alkyl alkyne and other aspects.Electric Literature of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 30, 2021, Garg, Anirban; Borah, Nobomi; Sultana, Jasmin; Kulshrestha, Akshay; Kumar, Arvind; Sarma, Diganta published an article.Formula: C9H9N3 The title of the article was Silica immobilized copper N-heterocyclic carbene: An effective route to 1,2,3-triazoles via azide-alkyne cycloaddition and multicomponent click reaction. And the article contained the following:

A new silica supported copper N-heterocyclic carbene (Cu-NHC@SiO2) complex is prepared and characterized by SEM (SEM), energy dispersive X-ray spectroscopy (EDX) and XPS analyses. This complex is an efficient and easily retrievable catalyst for 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition reaction as well as one-pot reaction using arylboronic acids. This catalytic system is also suitable for synthesis of 4-aryl-NH-1,2,3-triazoles from diverse benzaldehydes. Further, the catalyst can efficiently be recycled up to fifth cycle for all the three methods of 1,2,3-triazole synthesis through direct azide-alkyne cycloaddition and multi-component reactions. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Formula: C9H9N3

The Article related to silica immobilized copper nitrogen heterocyclic carbene catalyst, triazole preparation azide alkyne cycloaddition multicomponent click reaction, one pot reaction arylboronic acid triazole preparation and other aspects.Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On August 31, 2021, Saadat, Mostafa; Azizi, Najmedin; Qomi, Mahnaz published an article.Electric Literature of 5301-96-2 The title of the article was Sulfonic acid-functionalized magnetic carbon nitride as highly efficient ionic composite for sustainable assembly of 1,2,3-triazoles. And the article contained the following:

An efficient and straightforward method for constructing of biol. active 4-aryl-NH-1,2,3-triazoles I [Ar = Ph, 2-BrC6H4, 2-thienyl, etc.] by the 1,3-dipolar cycloaddition reaction of β-nitrostyrene and sodium azide in the presence of acidic graphitic carbon nitride (Fe3O4@g-C3N4-SO3H) ionic nanocomposite had developed. Using a magnetically recoverable acidic ionic catalyst allows eco-friendly and facile conversion and simplifies exptl. setup and work-up procedure that enables the direct synthesis of triazole derivatives under mild conditions. The designed catalytic system provided a broader scope under short reaction times in good to excellent yields. Fe3O4@g-C3N4-SO3H could be simply recovered by magnetic separation using an external magnet, maintaining stable activity up to five cycles without appreciable loss of activity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Electric Literature of 5301-96-2

The Article related to sulfonic acid functionalized graphitic carbon nitride iron oxide preparation, aryl triazole regioselective green preparation, beta nitrostyrene sodium azide dipolar cycloaddition iron oxide catalyst and other aspects.Electric Literature of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On March 3, 2010, Grimster, Neil; Zhang, Li; Fokin, Valery V. published an article.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Synthesis and Reactivity of Rhodium(II) N-Triflyl Azavinyl Carbenes. And the article contained the following:

Highly reactive rhodium(II) N-trifluoromethylsulfonyl azavinyl carbenes are formed in situ from NH-1,2,3-triazoles, triflic anhydride, and rhodium carboxylates. They rapidly and selectively react with olefins, providing cyclopropane carboxaldehydes and 2,3-dihydropyrroles in generally excellent yields and high enantio- and diastereoselectivity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole triflic anhydride chiral rhodium carboxylate catalyst, rhodium azavinyl carbene triflyl derivative formation alkene cyclopropanation, cyclopropane carboxaldehyde stereoselective preparation, alkene rhodium triflyl azavinyl carbene dipolar cycloaddition, dihydropyrrole derivative regioselective preparation and other aspects.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics