Category: 5301-96-2

On November 23, 2016, Wu, Luyong; Wang, Xianghui; Hui, Yang; Lin, Qiang; Huang, Qinglan; Tan, Zhiqiang published a patent.COA of Formula: C9H9N3 The title of the patent was Synthetic method of NH-1,2,3-triazole compound. And the patent contained the following:

The present invention relates to synthetic method of NH-1,2,3-triazole. The method comprises the steps of: carrying out one-pot reaction of aldehyde, nitro compound, sodium azide, solvent and additive for 1-8 h at 80-150 °C, and carrying out post treatment after reaction to obtain NH-1,2,3-triazole. With cheap and easily available aldehyde, nitro compound and sodium azide as raw materials, NH-1,2,3-triazole compound is easily prepared The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).COA of Formula: C9H9N3

The Article related to synthetic triazole compound, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 11, 2013, Kuang, Chunxiang; Yang, Qing; Lixin, Juanzi; Wang, Xun; Li, Yonggang published a patent.Electric Literature of 5301-96-2 The title of the patent was Method for synthesizing 1H-1,2,3-triazole compounds. And the patent contained the following:

The title method comprises the steps of: taking p-toluenesulfonyl azide, aryl acetylene, a catalyst, a ligand and a solvent as a reaction system, performing reaction at 20-30°C under magnetic stirring for 10-60 min, adding a small amount of water into the reaction solution, heating, carrying out reaction at 80-130°C under magnetic stirring for 1-20 h, cooling reaction solution to room temperature, extracting, washing the organic layer, drying, vacuum distilling to remove solvent and obtain crude product, and separating and purifying by column chromatog. to obtain the the title product. According to this invention, inexpensive and easily available p-toluenesulfonyl azide and aryl acetylene are used as substrates, and NH-1,2,3-triazole compound can be easily and effectively synthesized under catalyst action. The method has the advantages of mild reaction condition, short reaction time, high safety, convenient operation, high reaction efficiency and low catalyst cost, and has potential application value. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Electric Literature of 5301-96-2

The Article related to triazole preparation cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wang, Liang; Pan, Liang; Chen, Qun; He, Mingyang published an article in 2017, the title of the article was Acidic ion-exchange resin-catalyzed synthesis of 4-aryl-1H-1,2,3-triazoles.Related Products of 5301-96-2 And the article contains the following content:

A series of 4-aryl-1H-1,2,3-triazole derivatives (I, Ar = Ph, 4-methylphenyl, 4-methoxyphenyl, etc.) were synthesized by 1,3-dipolar cycloaddition of nitroolefins with NaN3 using Amberlite IR-120 resin as the catalyst. Compared with conventional methods, good efficiency, mild reaction conditions and good substrate compatibility are the major advantages of the present protocol. In addition, the catalyst can be easily recovered by filtration, and can be reused for successive six runs with slight decrease in its activity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Related Products of 5301-96-2

The Article related to acidic ion exchange resin aryl triazole, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Related Products of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On July 21, 2010, Kuang, Chunxiang; Zhang, Wensheng; Yang, Qing published a patent.Formula: C9H9N3 The title of the patent was Method for preparing 4-aryl-1H-1,2,3-triazole. And the patent contained the following:

The title method comprises adding (Z)-β-bromo arylethylene, DMF and NaN3 into tube in nitrogen gas ambient, stirring, adding Pd2(dba)3 and Xantphos, sealing, reacting at 105-115°C for 30-40 h to obtain 4-aryl-1H-1,2,3-triazole. The prepared 4-aryl-1H-1,2,3-triazole may be used as indoleamine 2,3-dioxygenase inhibitor. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Formula: C9H9N3

The Article related to triazole aryl preparation ido inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 30, 2017, Bhagat, Ujjawal Kumar; Peddinti, Rama Krishna published an article.Recommanded Product: 5301-96-2 The title of the article was Base-Mediated Ring Opening of meso-Epoxides with 4-Aryl-NH-1,2,3-triazoles: Synthesis of trans-2-(Aryltriazolyl)cycloalkanols. And the article contained the following:

A novel method of nucleophilic ring-opening of meso-epoxides with 4-aryl-NH-1,2,3-triazoles has been developed under metal-free conditions. The epoxide-ring opening process was carried out in the presence of organic bases (DABCO/Et3N) in acetonitrile at 85°C to afford a regioisomeric mixture of trans-2-(4-aryl-2H-1,2,3-triazol-2-yl)cycloalkanols (2,4-disubstituted triazoles) as major adducts and trans-2-(4-aryl-1H-1,2,3-triazol-1-yl)cycloalkanols (1,4-disubstituted triazoles) as minor adducts in excellent combined chem. yields (isolated yield up to 99%). The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 5301-96-2

The Article related to ring opening nucleophilic regioselective meso epoxide aryltriazole, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On March 18, 2022, Jankovic, Dominik; Virant, Miha; Gazvoda, Martin published an article.Category: triazoles The title of the article was Copper-Catalyzed Azide-Alkyne Cycloaddition of Hydrazoic Acid Formed In Situ from Sodium Azide Affords 4-Monosubstituted-1,2,3-Triazoles. And the article contained the following:

Authors report a copper-catalyzed cycloaddition of hydrogen azide (hydrazoic acid, HN3) with terminal alkynes to form 4-substituted-1,2,3-triazoles in a sustainable manner. Hydrazoic acid was formed in situ from sodium azide under acidic conditions to react with terminal alkynes in a copper-catalyzed reaction. Using polydentate N-donor chelating ligands and mild organic acids, the reactions were realized to proceed at room temperature under aerobic conditions in a methanol-water mixture and with 5 mol % catalyst loadings to afford 4-substituted-1,2,3-triazoles in high yields. This method is amenable on a wide range of alkyne substrates, including unprotected peptides, showing diverse functional group tolerance. It is applicable for late-stage functionalization synthetic strategies, as demonstrated in the synthesis of the triazole analog of losartan. The preparation of orthogonally protected azahistidine from Fmoc-L-propargylglycine was realized on a gram scale. The hazardous nature of hydrazoic acid has been diminished as it forms in situ in <6% concentrations at which it is safe to handle. Reactions of distilled solutions of hydrazoic acid indicated its role as a reactive species in the copper-catalyzed reaction. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Category: triazoles

The Article related to triazole preparation green chem, azide alkyne cycloaddition copper, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On July 20, 2011, Kuang, Chunxiang; Wang, Xiaokun published a patent.SDS of cas: 5301-96-2 The title of the patent was Method for synthesis of 4-aryl-1H-1,2,3-triazole with 1,1-dibromo-1-alkene. And the patent contained the following:

A process for preparation of 4-aryl-1H-1,2,3-triazole with 1,1-dibromo-2-aryl-1-alkene and azides via cyclization in the presence of catalyst and ligand is disclosed. The claimed 4-aryl-1H-1,2,3-triazole is shown in structure I (Ar = substituted phenyl). The claimed title compound is prepared with 1,1-dibromo-2-aryl-1-alkene II and azides via cyclization in the presence of catalyst and ligand. The azide is sodium azide, silver azide, or lead azide. The catalyst is selected from CuI, copper acetate, copper sulfate, or ferric chloride. The ligand is chosen from ascorbate salt, L-proline, N,N-di-Me ethylenediamine, or cysteine. The obtained compound can be used in synthesis and modification of medicine. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).SDS of cas: 5301-96-2

The Article related to aryltriazole preparation dibromoarylalkene azide cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.SDS of cas: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On February 9, 2011, Kuang, Chunxiang; Jiang, Yubo; Wei, Jian published a patent.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the patent was Preparation of 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase inhibitors. And the patent contained the following:

The title compounds I (R = aryl), are prepared by cyclizing trans-RCHBrCHBrCO2H with NaN3 in DMSO in N2 ambient in the presence of CuI, Na ascorbate and CsCO3 in a tubular reactor at 105-115°C for 2-6 h, extracting with Et acetate, vacuum concentrating to obtain crude product; and purifying on chromatog. column with petroleum ether-Et acetate as eluent. The molar ratio of trans-RCHBrCHBrCO2H to NaN3, CuI, Na ascorbate, and CsCO3 is 1:1.0-1:3.0, 1:0.1-1:0.3, 1:0.2-1:0.6, and 1:2-1:4, resp. The invention has the advantages of easily available materials, low cost, simple operation, and suitability for large-scale production I can be used as indoleamine 2,3-dioxygenase inhibitors. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole aryl preparation indoleamine dioxygenase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On November 23, 2016, Chen, Yuxue; He, Wenying; Song, Xinming; Wu, Luyong; Huang, Qinglan published a patent.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the patent was Method for preparing 4-aryl-NH-1,2,3-triazole from aldehyde sodium bisulfite adduct. And the patent contained the following:

The invention relates to method for preparing 4-aryl- NH-1,2,3-triazole I from aldehyde sodium bisulfite adduct. The method comprises the steps of: carrying out one-pot reaction of aldehyde sodium bisulfite adduct, nitro compound, sodium azide, solvent and additive for 1-10 h at 60-150 °C, and carrying out post treatment after reaction to obtain 4-aryl-NH-1,2,3-triazole. With cheap and easily available aldehyde sodium bisulfite adduct, nitro compound and sodium azide as raw materials, 4-aryl-NH-1,2,3-triazole compound is easily prepared Compared with existing method, the method provided in the invention has cheap and easily available raw material, simple operation and high reaction efficiency. Said 4-aryl-NH-1,2,3-triazole compound has the formula I as shown in the claim text, in which Ar is C5-C10 aryl or C5-C10 hetero aryl, and R is selected from H, C1-C6 alkyl, etc. Said aryl formaldehyde is benzaldehyde or naphthaldehyde, and hetero aryl formaldehyde is pyridylaldehyde or thiophene carboxaldehyde. Said nitro compound is nitro C1-C6 alkyl, nitro C2-C6 carboxylate or nitro C2-C6 nitrile. Said additive is selected from sodium sulfite, triethylamine, etc. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to preparing aryl triazole aldehyde sodium bisulfite adduct, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On May 17, 2019, Song, Renjie; Yang, Yongzheng; Li, Jinheng published a patent.COA of Formula: C9H9N3 The title of the patent was Preparation method of 9-azacyclic substituted xanthene compound. And the patent contained the following:

The invention relates to a process for the preparation of 9-azacyclic substituted xanthene compounds (e.g., I) by using electrolysis method. For instance, the compound I was prepared via electrolysis reaction of 9H-xanthene with 1H-indazole in the presence electrolyte (n-Bu4NBF4), additive (methanesulfonic acid), in acetonitrile at room temperature under 10 mA for 2 h followed by purification as a white solid in 81% yield. The invention has simple process, mild reaction condition, environmental friendliness, high at. economy, wide suitable range of reaction substrate and high yield of target product. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).COA of Formula: C9H9N3

The Article related to azacyclic substituted xanthene preparation electrolysis, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics