Category: 5301-96-2

Li, Si-Yuan; Guan, Zhen-Yu; Xue, Jing; Zhang, Guang-Yi; Guan, Xiao-Yu; Deng, Qing-Hai published an article in 2020, the title of the article was Practical copper-catalyzed chloronitration of alkenes with TMSCl and guanidine nitrate.Application of 5301-96-2 And the article contains the following content:

A novel and practical chloronitration of alkenes in the presence of easily available TMSCl and guanidine nitrate was developed by using cheap copper sulfate pentahydrate as the catalyst. A variety of vic-chloronitro compounds were directly synthesized in good to excellent yields on up to 100 mmol scale under mild reaction conditions, and the resulting products could be smoothly transformed into the corresponding nitroalkenes and diverse nitro compounds bearing a vicinal nucleophilic “C”, “N” or “S” unit. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application of 5301-96-2

The Article related to nitroalkene preparation, alkene guanidine nitrate chloronitration, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Hydrocarbons (Saturated and Unsaturated Side Chains) and other aspects.Application of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 1, 2014, He, Yun; Sun, Erxiao; Zhao, Yi; Hai, Li; Wu, Yong published an article.Formula: C9H9N3 The title of the article was The one-pot synthesis of 4-aryl-1H-1,2,3-triazoles without azides and metal catalization. And the article contained the following:

In this study, a new methodol. for the one-pot synthesis of 4-aryl-1H-1,2,3-triazoles, e.g., I (R = H, Me, Cl, F, NO2, CN), from arylglyoxaldoxime semicarbazones is presented. 4-Aryl-1,2,3-triazoles were obtained in moderate to good yields via sodium dithionite and O2, which are all efficient, safe and inexpensive reagents. This reaction is more suitable for large-scale syntheses than those using hydrazoic acid, sodium azide, or organic azides. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Formula: C9H9N3

The Article related to arylglyoxaldoxime semicarbazone oxidative heterocyclization sodium dithionite oxygen, aryl triazole preparation, dithionite oxygen oxidative heterocyclization mediator, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Formula: C9H9N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 16, 2015, Quan, Xue-Jing; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles [Erratum to document cited in CA161:682131]. And the article contained the following:

On page 5730, structure 4a in Scheme 2 was published incorrectly, and subsequent text corresponding to this Structure is also incorrect; the correct structure, name, and text are given. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to erratum aryltriazole preparation toluenesulfonic acid mediated dipolar cycloaddition, dipolar cycloaddition nitroolefin sodium azide aryltriazole preparation erratum, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Vorona, Svetlana V.; Zevatskii, Yuri E.; Myznikov, Leonid V. published an article in 2019, the title of the article was Zinc (II) Chloride as Phase Transfer Catalyst and as Catalyst of Cycloaddition Azide Ion to Heterocumulenes and Terminal Alkynes in Organic Solvents.Name: 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

The system of NaN3-ZnCl2 in organic solvents was effective for azide ion cycloaddition to heterocumulenes and terminal alkynes. The reaction proceeded readily in the case of heterocumulenes, so these transformations fall into the category of click reactions. The study on the reaction mechanism showed that role of zinc salt consists in transferring azide ion to the organic phase and decreasing the energy barrier of nucleophilic addition of azide ion to the unsaturated substrate. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to isothiocyanate sodium azide zinc chloride catalyst cycloaddition, thiotetrazole preparation, carbodiimide sodium azide zinc chloride catalyst cycloaddition, aminotetrazole preparation, terminal alkyne sodium azide zinc chloride catalyst regioselective cycloaddition, triazole preparation and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 19, 2018, Bhagat, Ujjawal Kumar; Peddinti, Rama Krishna published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Asymmetric Organocatalytic Approach to 2,4-Disubstituted 1,2,3-Triazoles by N2-Selective Aza-Michael Addition. And the article contained the following:

Cycloalkenones (2-cyclohexen-1-one, 4,4-dimethyl-2-cyclohexen-1-one, 2-cyclopenten-1-one) underwent regio- and enantioselective aza-Michael reactions with aryl-1,2,3-triazoles in the presence of a nonracemic cinchonine-derived thiourea to yield nonracemic (oxocycloalkyl)aryltriazoles I [R = Ph, 3-MeOC6H4, 4-MeOC6H4, 4-MeC6H4, 4-i-PrC6H4, 2-ClC6H4, 4-ClC6H4, 2-O2NC6H4, 3-O2NC6H4, 2-BrC6H4, 4-BrC6H4, 2,5-(MeO)2C6H3, 3,4-(MeO)2C6H3, 2,3-Cl2C63, 2,4,5-(MeO)3C6H2, 2-methoxy-1-naphthyl; X = CH2, CMe2, bond] in 58-75% yields and in 44->99% ee (with 0-25% yields of regioisomeric products derived from N1-addition). The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to oxocycloalkyl aryltriazole regioselective enantioselective preparation, regioselective enantioselective aza michael addition aryltriazole cycloalkenone cinchonine thiourea, cinchonine thiourea catalyst regioselective enantioselective michael addition aryltriazole cycloalkenone and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Park, Gab-Man; Park, Hyun; Oh, Sangtae; Lee, Seokjoon published an article in 2017, the title of the article was Antimalarial activity of C-10 substituted triazolyl artemisinin.Computed Properties of 5301-96-2 And the article contains the following content:

Synthesis of C-10 substituted triazolyl artemisinins I [R = Ph, 4-MeC6H4, 3-ClC6H4, etc.], II and III [R = 4-Ph, 5-Ph, 5-(4-MeC6H4), 5-(3-ClC6H4), etc.] by the Huisgen cycloaddition reaction between dihydroartemisinins and variously substituted 1,2,3-triazoles was described. The antimalarial activities of 32 novel artemisinin derivatives I , II and III were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin I [R = 3-ClC6H4], II [R = 3-ClC6H4] and III [R = 5-(3-ClC6H4), 4-(3-ClC6H4)] showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2

The Article related to substituted triazolyl artemisinin preparation regioselective diastereoselective antimalarial human, dihydroartemisinin triazole huisgen cycloaddition, antimalarial activity, artemisinin, dihydroartemisinin, substituted triazolyl artemisinin, synthesis and other aspects.Computed Properties of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On August 20, 2021, Wang, Tao; Tang, Zongyuan; Luo, Han; Tian, Yi; Xu, Mingchuan; Lu, Qixing; Li, Baosheng published an article.HPLC of Formula: 5301-96-2 The title of the article was Access to (Z)-β-Substituted Enamides from N1-H-1,2,3-Triazoles. And the article contained the following:

A direct ring-opening/nucleophilic substitution reaction of N1-H-1,2,3-triazoles was described. Divergent (Z)-β-halogen- or sulfonyl-substituted enamides were stereospecifically synthesized in a tunable manner. This strategy might not only enable a new ring-opening method of N1-H-1,2,3-triazoles under non-metal catalysis and mild reaction conditions but also offer a good opportunity to reliably access versatile (Z)-β-substituted enamides that could be used as synthetic precursors for further synthetic transformations. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to acyl halide triazole tandem diastereoselective ring opening nucleophilic substitition, halovinyl amide preparation, sulfonate acyl chloride triazole multicomponent tandem ring opening substitition, amido vinylsulfonate preparation diastereoselective and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 5, 2021, Hazarika, Roktopol; Garg, Anirban; Chetia, Swadhin; Phukan, Parmita; Kulshrestha, Akshay; Kumar, Arvind; Bordoloi, Ankur; Kalita, Amlan Jyoti; Guha, Ankur Kanti; Sarma, Diganta published an article.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Magnetically separable ZnFe2O4 nanoparticles: a low cost and sustainable catalyst for propargyl amine and NH-triazole synthesis. And the article contained the following:

The multicomponent reaction (MCR) strategy for the construction of important mol. scaffolds is in trending nowadays and among them, A3-coupling stands in a significant position. Aldehyde, amine and alkynes are coupled in this particular reaction via C-H activation process. Herein, zinc ferrite nanoparticles are reported as magnetically separable heterogeneous catalyst for A3-coupling reaction with attractive attributes like excellent productivity, selectivity and better reusability. Moreover, the catalyst can also be effectively applied for the synthesis of various NH-triazoles in quant. yields. A plausible mechanism has been proposed for the synthesis of NH-triazoles followed by validation with computational study. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole preparation, magnetically separable zinc ferrite nanoparticle preparation multicomponent catalyst, aldehyde amine alkyne coupling zinc ferrite, nitromethane aldehyde sodium azide coupling zinc ferrite, propargyl amine preparation and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yan, Wuming; Liao, Tao; Tuguldur, Odbadrakh; Zhong, Cheng; Petersen, Jeffrey L.; Shi, Xiaodong published an article in 2011, the title of the article was Mitsunobu Reaction of 1,2,3-NH-Triazoles: A Regio- and Stereoselective Approach to Functionalized Triazole Derivatives.Synthetic Route of 5301-96-2 And the article contains the following content:

Mitsunobu reactions of primary, secondary, benzylic and allylic alcs. with 1,2,3-triazoles and 1,2,3-benzotriazole gave the N2-alkylated triazoles and benzotriazoles in most cases as the major regioisomers; N-alkylation reactions also occurred with high stereoselectivities when either trans-2-methyl-1-cycloalkanols or nonracemic alcs. were used as electrophiles. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to alkyl allylic benzylic triazole regioselective stereoselective preparation, regioselective mitsunobu reaction triazole benzotriazole alc, stereoselective regioselective mitsunobu reaction benzotriazole nonracemic alc methylcycloalkanol and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On October 6, 2017, Zhang, Lingling; Yi, Hong; Wang, Jue; Lei, Aiwen published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Visible-Light Mediated Oxidative C-H/N-H Cross-Coupling between Tetrahydrofuran and Azoles Using Air. And the article contained the following:

THF is a privileged structural moiety in many important organic compounds In this work, a simple and mild catalytic oxidative amination of THF mediated by visible-light catalysis was developed. The C(sp3)-H bond of THF was activated using mol. oxygen as a benign oxidant. Besides, a variety of azoles could be tolerated, providing a green route for N-substituted azoles, e.g., I. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to azole thf oxidative cross coupling amination light blue led, thf azole hybrid preparation, visible light oxidative amination mediator, methyltriphenyl acridinium perchlorate oxidative cross coupling amination photocatalyst and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics