Category: 56602-33-6

《Synthesis of functionalized magnetic nanoparticles, their conjugation with the siderophore feroxamine and its evaluation for bacteria detection》 was published in Journal of Visualized Experiments in 2020. These research results belong to Martinez-Matamoros, Diana; Castro-Garcia, Socorro; Romano, Gabriela Ojeda; Balado, Miguel; Rodriguez, Jaime; Lemos, Manuel L.; Jimenez, Carlos. Application of 56602-33-6 The article mentions the following:

In the present work, the synthesis of magnetic nanoparticles, its coating with SiO2, followed by its amine functionalization with (3-aminopropyl)triethoxysilane (APTES) and its conjugation with deferoxamine, a siderophore recognized by Yersinia enterocolitica, using a succinyl moiety as a linker are described. Magnetic nanoparticles (MNP) of magnetite (Fe3O4) were prepared by solvothermal method and coated with SiO2 (MNP@SiO2) using the Stöber process followed by functionalization with APTES (MNP@SiO2 @NH2). Then, feroxamine was conjugated with the MNP@SiO2 @NH2 by carbodiimide coupling to give MNP@SiO2 @NH2 @Fa. The morphol. and properties of the conjugate and intermediates were examined by eight different methods including powder XRay diffraction (XRD), Fourier transform IR spectroscopy (FT-IR), Raman spectroscopy, XPS, transmission electron microscopy (TEM) and energy dispersive X-Ray (EDX) mapping. This exhaustive characterization confirmed the formation of the conjugate. Finally, in order to evaluate the capacity and specificity of the nanoparticles, they were tested in a capture bacteria assay using Yersinia enterocolitica. In addition to this study using ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V), there are many other studies that have used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Application of 56602-33-6) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Application of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2016,Amin, Kamelia M.; Abd El-Meguid, Eman A.; El-Assaly, Samy A.; El-Hamouly, Wageeh S. published 《Synthesis, antibreast cancer activity and docking study of some novel 4-(benzo [d] thiazol-2-yl) phenyl moiety as CDK2 inhibitors》.International Journal of Pharmacy and Technology published the findings.Computed Properties of C12H22F6N6OP2 The information in the text is summarized as follows:

Some novel sulfonamides, Schiff’s bases and pyrrole derivatives attached to 4-benzo[d]thiazol-2-yl were prepared Some of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF-7) in comparison with doxorubicin; the urea derivative 6a exhibited the highest activity. Mol. docking into CDK2 has been done for lead optimization of the compounds in study as potential CDK2 inhibitors; compound 8b showed the lowest binding score. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Computed Properties of C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Computed Properties of C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Naclerio, George A.; Abutaleb, Nader S.; Alhashimi, Marwa; Seleem, Mohamed N.; Sintim, Herman O. published an article in 2021. The article was titled 《N-(1,3,4-oxadiazol-2-yl)benzamides as antibacterial agents against Neisseria gonorrhoeae》, and you may find the article in International Journal of Molecular Sciences.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V) The information in the text is summarized as follows:

The Centers for Disease Control and Prevention (CDC) recognizes Neisseria gonorrhoeae as an urgent-threat Gram-neg. bacterial pathogen. Addnl., resistance to frontline treatment (dual therapy with azithromycin and ceftriaxone) has led to the emergence of multidrug-resistant N. gonorrhoeae, which has caused a global health crisis. The drug pipeline for N. gonorrhoeae has been severely lacking as new antibacterial agents have not been approved by the FDA in the last twenty years. Thus, there is a need for new chem. entities active against drug-resistant N. gonorrhoeae. Trifluoromethylsulfonyl (SO2CF3), trifluoromethylthio (SCF3), and pentafluorosulfanyl (SF5) containing N-(1,3,4-oxadiazol-2-yl)benzamides are novel compounds with potent activities against Gram-pos. bacterial pathogens. Here, we report the discovery of new N-(1,3,4-oxadiazol-2- yl)benzamides (HSGN-237 and -238) with highly potent activity against N. gonorrhoeae. Addnl., these new compounds were shown to have activity against clin. important Gram-pos. bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), and Listeria monocytogenes (min. inhibitory concentrations (MICs) as low as 0.25 μg/mL). Both compounds were highly tolerable to human cell lines. Moreover, HSGN-238 showed an outstanding ability to permeate across the gastrointestinal tract, indicating it would have a high systemic absorption if used as an anti-gonococcal therapeutic.((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis and Evaluations of “”1,4-Triazolyl Combretacoumarins”” and Desmethoxy Analogs》 was written by Khandaker, Tashrique A.; Hess, Jessica D.; Aguilera, Renato; Andrei, Graciela; Snoeck, Robert; Schols, Dominique; Pradhan, Padmanava; Lakshman, Mahesh K.. Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)This research focused ontriazolyl combretacoumarin preparation anticancer; azidocoumarin preparation terminal alkyne cycloaddition copper catalyst; Coumarin; CuAAC; alkyne; combretastatin; copper; triazole. The article conveys some information:

1,4-Triazolyl combretacoumarins have been prepared by linking the trimethoxyarene unit of combretastatin A4 with coumarins, via a 1,2,3-triazole. For this, 4-azidocoumarins were accessed by a sequential two-step, one-pot reaction of 4-hydroxycoumarins with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), followed by reaction with NaN3. In the reaction with BOP, a coumarin-derived phosphonium ion intermediate seems to form, leading to an O4-(benzotriazolyl)coumarin derivative For the CuAAC reaction of azidocoumarins with 5-ethynyl-1,2,3-trimethoxybenzene, catalytic [(MeCN)4Cu]PF6 in CH2Cl2/MeOH with 2,6-lutidine, at 50 oC, was suitable. The 4-azidocoumarins were less reactive as compared to PhN3 and the NBO coefficients of the azido groups were compared by DFT anal. Compound solubility was a problem in biol. assays. On the basis of the biol. and solubility data of one 1,4-triazolyl combretacoumarin, four analogs lacking one or two methoxy groups were synthesized. Reactivity differences among the phenylacetylenes were noted and the NBO coefficients of the alkynes were compared by DFT anal. In cytotoxicity assays, 1-phenyl-4-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole showed activity in CEM and MDA-MB-231 cell lines by apoptosis. The desmethoxy 6-bromo-4-(4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl)-2H-chromen-2-one also showed cytotoxicity against the two cell lines, but this did not appear to be consistent with apoptosis. The antiviral activity of the compounds was unremarkable. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Reference of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2017,Castro, Vida; Noti, Christian; Chen, Wenqian; Cristau, Michele; Livignston, Andrew; Rodriguez, Hortensia; Albericio, Fernando published 《Novel Globular Polymeric Supports for Membrane-Enhanced Peptide Synthesis》.Macromolecules (Washington, DC, United States) published the findings.SDS of cas: 56602-33-6 The information in the text is summarized as follows:

Membrane-enhanced peptide synthesis (MEPS), a technique that combines liquid-phase peptide synthesis (LPPS) with organic solvent nanofiltration (OSN), has emerged as a new methodol. to tackle current challenges in solid-phase peptide synthesis (SPPS), the current strategy of choice for the preparation of peptides. This new technol. platform is scalable beyond kilogram scale, automatable, and compatible with established Fmoc chem., as it combines chem. in solution with expedient membrane purification Here we screened novel highly rejected soluble polymeric supports and studied their application for the preparation of a model peptide. Our findings make a significant contribution to the development of MEPS. In addition to this study using ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V), there are many other studies that have used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6SDS of cas: 56602-33-6) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It acts as a substitute for (Benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) reagent.SDS of cas: 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2016,Gunasekara, Roshan W.; Zhao, Yan published 《Enhancing binding affinity and selectivity through preorganization and cooperative enhancement of the receptor》.Chemical Communications (Cambridge, United Kingdom) published the findings.Electric Literature of C12H22F6N6OP2 The information in the text is summarized as follows:

When direct host-guest binding interactions are weakened by unfavorable solvent competition, guest-triggered intra-receptor interactions could be used to augment the binding. This strategy of cooperative enhancement, when combined with the principle of preorganization, yielded a strong and selective receptor for binding citrate in water. In the experiment, the researchers used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Electric Literature of C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Electric Literature of C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Journal of Enzyme Inhibition and Medicinal Chemistry included an article by Choi, Eun-Ju; Ryu, Young Bae; Tang, Yujiao; Kim, Bo Ram; Lee, Woo Song; Debnath, Trishna; Fan, Meiqi; Kim, Eun-Kyung; Lee, Hyun-Su. Product Details of 56602-33-6. The article was titled 《Effect of cinnamamides on atopic dermatitis through regulation of IL-4 in CD4+ cells》. The information in the text is summarized as follows:

This study aimed to evaluate the effects of cinnamamides on atopic dermatitis (AD) and the mechanisms underlying these effects. To this end, the actions of two cinnamamides, (E)-3-(4-hydroxyphenyl)-N-phenylethyl acrylamide (NCT) and N-trans-coumaroyltyramine (NCPA), were determined on AD by orally administering them to mice. Oral administration of the cinnamamides ameliorated the increase in epidermal and dermal thickness as well as mast cell infiltration. Cinnamamides suppressed serum Ig (Ig) levels and expression of T-helper (Th)1/Th2 cytokines. Moreover, cinnamamides suppressed interleukin (IL)-4, which plays a crucial role in preparing naive CD4+ T cells, and decreased the cervical lymph node size and weight Interestingly, in almost all cases, NCPA exhibited higher anti-AD activity compared to NCT. These results strongly indicate that NCPA may have potential as an anti-AD agent, and further mechanistic comparative studies of NCT and NCPA are required to determine the cause of differences in biol. activity. In addition to this study using ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V), there are many other studies that have used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Product Details of 56602-33-6) was used in this study.

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Product Details of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lin, Qianming; Ke, Chenfeng published an article in 2022. The article was titled 《Conductive and anti-freezing hydrogels constructed by pseudo-slide-ring networks》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).COA of Formula: C12H22F6N6OP2 The information in the text is summarized as follows:

Stretchable, tough, and anti-freezing hydrogels were prepared using partially carboxymethylated polyrotaxanes and polyacrylamides. The carboxylic acid groups of α-cyclodextrins in the polyrotaxane and the amide groups in polyacrylamide are hydrogen-bonded, affording a pseudo-slide-ring network, greatly enhancing the hydrogels’ macroscale mech. properties, anti-freezing features, and elec. conductivity for the fabrication of a cold-temperature strain sensor. In the experimental materials used by the author, we found ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6COA of Formula: C12H22F6N6OP2)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.COA of Formula: C12H22F6N6OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)In 2015 ,《A Novel Bio-Orthogonal Cross-Linker for Improved Protein/Protein Interaction Analysis》 appeared in Analytical Chemistry (Washington, DC, United States). The author of the article were Nury, Catherine; Redeker, Virginie; Dautrey, Sebastien; Romieu, Anthony; van der Rest, Guillaume; Renard, Pierre-Yves; Melki, Ronald; Chamot-Rooke, Julia. The article conveys some information:

The variety of protein crosslinkers developed in recent years illustrates the current requirement for efficient reagents optimized for mass spectrometry (MS) anal. To date, the most widely used strategy relies on com. crosslinkers that bear an isotopically labeled tag and N-hydroxysuccinimid-ester (NHS-ester) moieties. Moreover, an enrichment step using liquid chromatog. is usually performed after enzymic digestion of the crosslinked proteins. Unfortunately, this approach suffers from several limitations. First, it requires large amounts of proteins. Second, NHS-ester crosslinkers are poorly efficient because of their fast hydrolysis in water. Finally, data anal. is complicated because of uneven fragmentation of complex isotopic crosslinked peptide mixtures We therefore synthesized a new type of trifunctional crosslinker to overrule these limitations. This reagent, named NNP9, comprises a rigid core and bears two activated carbamate moieties and an azido group. NNP9 was used to establish intra- and intermol. crosslinks within creatine kinase, then to map the interaction surfaces between α-Synuclein (α-Syn), the aggregation of which leads to Parkinson’s disease, and the mol. chaperone Hsc70. We show that NNP9 crosslinking efficiency is significantly higher than that of NHS-ester com. crosslinkers. The number of crosslinked peptides identified was increased, and a high quality of MS/MS spectra leading to high sequence coverage was observed Our data demonstrate the potential of NNP9 for an efficient and straightforward characterization of protein-protein interfaces and illustrate the power of using different crosslinkers to map thoroughly the surface interfaces within protein complexes. After reading the article, we found that the author used ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V))

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Quality Control of ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 56602-33-6In 2020 ,《Double-layered honeycomb architectures constructed via hierarchical self-assembly of hexagonal spin crossover cobalt(II) metallacycles》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Akiyoshi, Ryohei; Kuroiwa, Keita; Sakuragi, Mina; Yoshimoto, Soichiro; Ohtani, Ryo; Nakamura, Masaaki; Lindoy, Leonard F.; Hayami, Shinya. The article contains the following contents:

A hexagonal cobalt(II) metallacycle and its “”lipid packaged”” derivatives, [Co6(R-bisterpy)6]X12 (R = H, OC16H33, OC27H55; X = BF4, C12-Glu), have been synthesized and characterized. The compounds incorporating BF4- anions formed sphere-like aggregates while the compounds with C12-Glu lipid anions gave double-layered honeycomb architectures composed of hexagonal stacked tubular structures, which exhibit spin crossover behavior. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Related Products of 56602-33-6)

((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.Related Products of 56602-33-6

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics