Category: 6086-21-1

6086-21-1, Adding some certain compound to certain chemical reactions, such as: 6086-21-1, name is 1-Methyl-1,2,4-triazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6086-21-1.

Example 133.; Preparation of 8-(1-ethyl-propyl)-3-[3-methoxy-5-(2-methyl-2H-[1,2,4]triazol-3-yl)- thiophen-2-yl]-2,6-dimethyl-imidazo[1,2-b]pyridazine.; A. 5-Bromo-1-methyl-1H-[1,2,4]triazole.; EPO To a -78 ¡ãC solution of l-methyl-1H-[1,2,4]triazole (1.0 mL, 13.20 mmol) and TEtaF (100 mL) is added 1.6 M n-BuLi (8.70 mL, 13.86 mmol). After 45 minutes 1,2- dibromo-l,1,2,2-tetrafluoro-ethane (1.76 mL, 14.52 mmol) is added, the solution is warmed to ambient temperature and stirred for 2 hours. The solution is diluted with EtOAc (200 mL), washed with water (150 mL), brine (150 mL), dried over MgSO4, filtered and concentrated to furnish the title compound (1.37 g, 8.46 mmol, 64percent). 1H NMR (CDCl3) delta 3.82 (s, 3H), 7.78 (s, 1H). LC/MS (m/z): calcd. for C3H4BrN3 (M+H)+: 162.0; found: 161.9.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6086-21-1.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/102194; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6086-21-1 as follows. 6086-21-1

(a) To a solution of 19.6 g (0.236 mol) of 1-methyl-1,2,4-triazole in 350 ml of ether at -78¡ã C. under argon was added n-butyllithium (91 ml, 0.236 mol, 2.5M in hexane) within a 30 min period and the mixture was stirred at -78¡ã C. for 2 h, and followed with the addition of 17.3 g (0.236 mol) of DMF in 45 ml of ether. The mixture was slowly warmed to 0¡ã C., and was stirred at 0¡ã C. for 2 hours, then 25 g of silica gel was added to the mixture. The whole suspension was packed on a silica column with methylene chloride and the eluent (methylene chloride/ether, 4:1) was concentrated to afford 17.75 g (67.7percent) of 1-methyl-1,2,4-triazolyl-5-carboxaldehyde, as a yellow oil.

According to the analysis of related databases, 6086-21-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sterling Winthrop Inc.; US5569655; (1996); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics