Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626248-56-4, name is 3-(2H-1,2,3-Triazol-2-yl)aniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 626248-56-4
Reactor A was charged with solid ethyl 4-chloro-2-methylthio-5-pyrimidine carboxylate (1.00kg). Reactor A was then charged with absolute ethanol (5.OOL, 4.0kg). Reactor A was then charged with triethylamine (0.62L, 0.45kg). The content of Reactor A was then cooled to about 20 C. Reactor A was then charged 3-amino-N-phenyl-triazole (0.70kg). The reaction mixture was slowly heated to 30-40 C over about 1 hour to give an off white suspension. The contents of Reactor A was stirred between 30-40 C for about 6 hours. 8) Sample solution for ion pair chromatography for less than 1% (area) by HPLC of ethyl 4-chloro-2-methylthio-5-pyrimidine carboxylate. If the sample result complies with criterion proceed to the next step, otherwise agitate for an additional 2 hours between 30-40C and sample again. The reaction mixture generally turns into almost unmixable slurry toward the end of the reaction. The contents of Reactor A was cooled to about 20 C. Tap water (8.OOL, 8.00kg) was charged into Reactor B and the temperature of the contents of Reactor B was adjusted to about 15 C. The contents of Reactor B was charged into Reactor A, while maintaining the temperature at about 15C in Reactor A. The contents of Reactor A was stirred for about 30 minutes at about 15C. The contents of Reactor A was filtered using a filter cloth of about 8im or smaller to accommodate the particle size, or an oyster-style filter with a 3 – 5 im polypropylene filter cloth. Reactor B was charged with tap water (10.OOL, 10.00kg) and half the contents of Reactor B was charged to the filter to wash the solids. The remaining contents of Reactor B was charged to the filter to wash the solids. Reactor B was charged with methyl tert-butyl ether (3.OOL, 2.22kg). The contents of Reactor B was then charged to the filter to wash the solids. The contents of the filter was dried under vacuum such as in a vacuum tray dryer at about 55 C for about 12 hours, until the water (by Karl Fischer) is < 1 % w/w.The title compound was prepared according to Process Example 1 starting with 25.0 kg of ethyl 4-chloro-2-methylthio-5-pyrimidine, 11.25 kg triethylamine, 100 kg absolute ethanol and 17.5 kg 3-amino-N-phenyl-triazole. A 90.4% yield of the title compound was obtained.
According to the analysis of related databases, 626248-56-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; PANDEY, Anjali; WO2014/152768; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics