Category: 63598-71-0

Ponomareov, O. A. published the artcileNature of electronic transitions in absorption spectra of phenyl derivatives of 1,3,4-sym-triazole, Quality Control of 63598-71-0, the publication is Teoreticheskaya i Eksperimental’naya Khimiya (1993), 29(2), 169-73, database is CAplus.

The absorption spectra of 1,3,4-sym-triazole, its mono-, di-, and tri-Ph derivatives were calculated in π electron approach by PPP CI procedure. Application of the special quantum-chem. excitation indexes allows to classify transitions as being either local or entire mol. in character. The dependence of characteristics on π system structure for the latter case was studied.

Teoreticheskaya i Eksperimental’naya Khimiya published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, Quality Control of 63598-71-0.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Toda, Fumio published the artcileFreezing the equilibrium of 1,2,4-triazole by complex formation with 1,1-bis(2,4-dimethylphenyl)-2-butyn-1-o1, and x-ray crystal structure of the complex, COA of Formula: C2H3N3, the publication is Chemistry Letters (1987), 2317-20, database is CAplus.

Of the two tautomeric isomers of 1,2,4-triazole, 1,2,4-triazacyclopenta-3,5-diene and 1,2,4-triazacyclopenta-2,5-diene, the former was isolated as a 1:1 complex with the title host compound X-ray anal. of the complex reveals that the two mol. components are linked by hydrogen bonds.

Chemistry Letters published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C11H12O4, COA of Formula: C2H3N3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Enmanji, Koe published the artcileEstimation of the relative efficiency of antioxidants by using the decolorization rates of a nickel dithiolate complex, Computed Properties of 63598-71-0, the publication is Nippon Kagaku Kaishi (1979), 796-8, database is CAplus.

Fading phenomena of a solution of bis[4-(dimethylamino)dithiobenzil]nickel(0) complex in 1,2-dichloroethane were investigated in the presence of THF as a radical generator. The decoloration proceeded as a 1st order reaction with respect to the concentration of the Ni complex and a half order with respect to the concentration of THF. Effects of some antioxidants on the fading rates were also examined

Nippon Kagaku Kaishi published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, Computed Properties of 63598-71-0.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Guerret, Olivier published the artcile1,2,4-Triazole-3,5-Diylidene: A Building Block for Organometallic Polymer Synthesis, Category: triazoles, the publication is Journal of the American Chemical Society (1997), 119(28), 6668-6669, database is CAplus.

Addition of two equivalent of silver(I) acetate to the diquaternary salt of 1,2,4-triazole, leads after crystallization to a one-dimensional polymer I, featuring coplanar 1,2,4-triazol-3,5-bis(ylidene) ligands coordinated to silver(I). The polymer I is insoluble in classical solvents and has been characterized by a single crystal x-ray diffraction study.

Journal of the American Chemical Society published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, Category: triazoles.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Guerret, Olivier published the artcile1,2,4-Triazolium-5-ylidene and 1,2,4-triazol-3,5-diylidene as new ligands for transition metals, Synthetic Route of 63598-71-0, the publication is Journal of Organometallic Chemistry (2000), 600(1-2), 112-117, database is CAplus.

Ab initio calculations (RHF-SCF-DZP and MP4) show the 4,5-dihydro-1H-1,2,4-triazolium-5-ylidene and 1,2,4-triazolidine-3,5-diylidene (4a) are true min. on the potential surface. As expected, 4a is much higher in energy than its triazole isomers (1H, 3H and 4H-1,2,4-triazoles) and the 2,3-dihydro-4H-1,2,4-triazol-3-ylidene. NaOMe adds to the triflate salts of diquaternary 1,2-dimethyl-4-alkyl-1H-1,2,4-triazoliums (9b,c; alkyl = Me, ⁱPr) to give the corresponding monocationic heterocycles, 4-alkyl-4,5-dihydro-1,2-dimethyl-5-methoxy-1H-1,2,4-triazolium triflates, in 70 and 50% yield, resp. One equivalent of Ag(I) acetate reacts with 9b leading to the bis(1,2,4-trimethyl-4,5-dihydro-1H-1,2,4-triazolium-5-ylidene)silver(I) complex (11b) in 80% yield. Under the same exptl. conditions, but using two equivalent of Ag(I) acetate, solid-state 1-dimensional polymers 12‘b,c featuring the coplanar 4-alkyl-1,2-dimethyl-1,2,4-triazolidine-3,5-diylidene ligands coordinated to Ag(I) were obtained in 90% yield. 12‘C was fully characterized including a single-crystal x-ray diffraction study.

Journal of Organometallic Chemistry published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, Synthetic Route of 63598-71-0.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Shen, Lijiang published the artcileEvaluation of C-5 Propynyl Pyrimidine-Containing Oligonucleotides In Vitro and In Vivo, Product Details of C2H3N3, the publication is Antisense & Nucleic Acid Drug Development (2003), 13(3), 129-142, database is CAplus and MEDLINE.

Inclusion of C-5 propynyl pyrimidines in phosphorothioate antisense oligonucleotides (ASOs) has been shown to significantly increase their potency for inhibiting gene expression in vitro. This increased potency is believed to be the result of enhanced binding affinity to target RNA. Our results show that C-5 propynyl pyrimidine-modified oligonucleotides caused an increase in the melting temperature (Tm) of both oligodeoxynucleotides (ODNs) and 2′-O-(2-methoxy)ethyl (2′-MOE)-modified oligonucleotides. The in vitro data show a moderate increase in potency for an antisense oligodeoxynucleotide containing C-5 propynyl pyrimidines targeting the murine PTEN (MMAC1) transcript. Second-generation 2′-MOE chimeric ASOs containing C-5 propynyl pyrimidines showed no improvement in potency in PTEN target reduction in vitro or in vivo compared to their nonpropyne-modified parent. These results suggest that increasing affinity for target RNA beyond that achieved with the 2′-MOE modification does not further increase potency in cell-based assays. To evaluate whether this observation held true for in vivo applications, we evaluated both compounds in mice. We were unable to establish a dose-response relationship with C-5 propynyl pyrimidine-modified ODNs because of severe toxicity. The toxicity was characterized by mortality in animals receiving 50 mg/kg and an increase in infiltrating cells and apoptotic cells in livers of mice receiving 20 mg/kg. C-5 propynyl pyrimidine-modified chimeric oligonucleotides exhibited decreased hepatotoxicity compared with C-5 propynyl-modified ODNs but did not exhibit an increase in potency compared with unmodified chimeric oligonucleotides. The hepatotoxicity could be further limited if incorporation of propynyl pyrimidines was restricted to 2′-MOE nucleosides.

Antisense & Nucleic Acid Drug Development published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C17H18N3NaO3S, Product Details of C2H3N3.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Singh, S. P. published the artcileThiosemicarbazide and triazole derivatives as potential antibacterial and antifungal agents, Safety of 4H-1,2,4-Triazole, the publication is Bokin Bobai (1983), 11(1), 15-19, database is CAplus.

Nine N¹-(4′-chlorophenylthioacetyl)thiosemicarbazides (I; R = aryl), 9 3-(4′-chlorophenylthiomethyl)-5-mercapto-1,2,4-triazoles (II; R = aryl), 5 3-(4′-chlorophenyl)-5-thiomethylbenzinidazol-2-yl-1,2,4-triazoles (III; R = aryl), and 6 3-(4′-chlorophenylthiomethyl)-5-mercaptoacetylureido-1,2,4-triazoles (IV; R and R¹ = aryl) were screened for their antibacterial activities against Escherichia coli and Pseudomonas aeruginosa and their antifungal activities against Alternaria tendus and Helminthosporium gramineum. Most of the compounds exhibited promising antimicrobial activities and their structure-activity relations are discussed.

Bokin Bobai published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C17H14O5, Safety of 4H-1,2,4-Triazole.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Andrianov, V. G. published the artcileDependence of the reactivity of five-membered heterocycles on their structure. 3. Proton affinity of azoles and oxazoles, SDS of cas: 63598-71-0, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1989), 508-11, database is CAplus.

Predictions of proton affinity of azoles and oxazoles with the economical STO-3G basis differ little from those using an expanded 6-31^** basis and CI, and correlate with exptl. values with identical precision; MNDO gives poorer results. A linear equation correlating proton affinity with pK_a of protonated azole tautomers afforded a prediction of -7.64 for the pK_a of furazan conjugate acid.

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, SDS of cas: 63598-71-0.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Zhilitskaya, L. V. published the artcileReaction of Imidazoles and Triazoles with 1-(Benzotriazol-1-yl)-2-iodoethanone, SDS of cas: 63598-71-0, the publication is Russian Journal of Organic Chemistry (2018), 54(10), 1531-1536, database is CAplus.

Reactions of 2-methyl-1H-imidazole, 1H-benzimidazole, 4H-1,2,4-triazole, and 1H-benzotriazole with 1-(1H-benzotriazol-1-yl)-2-iodoethan-1-one in the absence of a base gave the corresponding N-mono- and N,N’-disubstituted derivatives 4H-1,2,4-Triazole-3-thiol reacted with 1-(1H-benzotriazol-1-yl)-2-iodoethan-1-one to afford 1-([1,3]thiazolo[2,3-c][1,2,4]triazol-5-yl)-1H-benzotriazolium triiodide.

Russian Journal of Organic Chemistry published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C9H9NO6S, SDS of cas: 63598-71-0.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Piedrahita-Bello, Mario published the artcileDrastic lattice softening in mixed triazole ligand iron(II) spin crossover nanoparticles, Category: triazoles, the publication is Chemical Communications (Cambridge, United Kingdom) (2019), 55(33), 4769-4772, database is CAplus and MEDLINE.

A series of spin-crossover (SCO) coordination nanoparticles (∼60 nm) with the general formulas [Fe(Htrz)_1+y-x(trz)_2-y(NH₂trz)_x](BF₄)_y·nH₂O (x = 0, 0.1, 0.2 and 0.3) were synthesized in concentrated solutions without using any surfactant or polymer. The nanoparticle powders were investigated by TEM, powder x-ray diffraction, magnetometry, calorimetry, Raman/IR spectroscopies, elemental anal. and ⁵⁷Fe Mossbauer spectrometry. Remarkably, the latter revealed a large decrease of the lattice stiffness when incorporating a small amount of amino-triazole ligand, reflected by the drop of the Debye temperature from 285 K (x = 0) to 205 K (x = 0.3). This collapse of the lattice cohesion was attributed to a reorganization of the supramol. interactions between the Fe-triazole chains. This effect on the SCO properties is also discussed.

Chemical Communications (Cambridge, United Kingdom) published new progress about 63598-71-0. 63598-71-0 belongs to triazoles, auxiliary class Triazole, name is 4H-1,2,4-Triazole, and the molecular formula is C2H3N3, Category: triazoles.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics