New discoveries in chemical research and development in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world.81581-05-7, name is Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate
Example 42: 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylic acidTo a mixture of ethyl 1-(4-methoxybenzyl)-1 H-1 ,2,3-triazole-4-carboxylate (190.0 g, 0.73 mol) and MeOH/H2O (350 mL/100 mL) was added LiOH. H2O (42.0 g, 0.97 mol) in portions at 0 0C and the reaction mixture was stirred at room temperature overnight. The mixture was evaporated, the residue was diluted with water (250 mL), then extracted with Et2O (3×75 mL) to remove neutral impurities. The aqueous layer was adjusted to pH = 3-4 with cone. HCI and the precipitate was filtered to afford the title compound (160 g, 94.0%) as a white solid.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of Ethyl 1-(4-methoxybenzyl)-1H-1,2,3-triazole-4-carboxylate ,and how the biochemistry of the body works.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/4096; (2008); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics