Liu, Tao published the artcileSynthesis of new antifungal agents-triazole propanol derivatives containing nitrogen, Quality Control of 86386-77-8, the publication is Zhongguo Yaowu Huaxue Zazhi (2002), 12(6), 333-336, database is CAplus.
1-(R-amino)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)- 2-propanol (R = R’-Ph, cyclopropyl, or Me and R’ = H, chloro, Me, ethoxy, or methoxy) hydrochloride or succinate were synthesized by acylating 1,3-difluorobenzene with chloroacetyl chloride, substituting with 1H-1,2,4-triazole, allowing to react with trimethylsulfoxonium iodide, and ring-opening with RNH2. 11 Compounds were synthesized, their structures were confirmed by IR and 1H-NMR, and their antifungal activities were tested. Among the 11 compounds, 10 compounds had antifungal activities to different degrees.
Zhongguo Yaowu Huaxue Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Quality Control of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics