Sun, Qing-Yan published the artcileSynthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substituted-phenyl)piperazin-1-yl]propan-2-ols as antifungal agents, Formula: C12H13F2N3O4S, the publication is European Journal of Medicinal Chemistry (2007), 42(8), 1151-1157, database is CAplus and MEDLINE.
1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substituted-phenyl)piperazin-1-yl]propan-2-ols such as I were designed and synthesized from the structure-activity relations and antimycotic mechanism of azole antifungal agents. Their structures were confirmed by elemental anal., IR, MS, 1H NMR and 13C NMR. Results of preliminary antifungal tests against six human pathogenic fungi (Candida albicans, Candida parapsilosis, Cryptococcus neoformans, Candida tropicalis, inherently fluconazole-resistant Candida krusei, Candida glabrata) in vitro showed that all title compounds exhibited activity against fungi tested to some extent except against C. tropicalis.
European Journal of Medicinal Chemistry published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C7H10BNO4S, Formula: C12H13F2N3O4S.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics