New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. name: 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid
HOBt.H2O (1.1 g, 7.4 mmol) and EDC.HCl (1.4 g, 7.4 mmol) were added to a solution of 3,3-diethoxypropan-1-amine (0.96 mL, 5.9 mmol) and 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid (1.0 g, 4.9 mmol) in DMF (18 mL), followed by stirring at room temperature for 3 hours. An aqueous NaHCO3 solution was added to the reaction solution, followed by extraction with EtOAc. The organic layer was washed with water and brine and was dried with Na2SO4. The desiccant was then removed by filtration, and the solvent was distilled off under reduced pressure. The resulting residue was purified by column chromatography (KP-Sil: 25 g, hexane/EtOAc=85/15 to 0/100) to give the titled compound (1.6 g, colorless solid). MS (ESI pos.) m/z: 333 [M+H]+
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Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Suzuki, Ryo; Futamura, Aya; Abe, Masahito; Kashiwa, Shuhei; Hattori, Nobutaka; Nozawa, Dai; Ohta, Hiroshi; Araki, Yuko; US2014/81025; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics