Chai, Xiaoyun published the artcileDesign, synthesis and molecular docking studies of novel triazole as antifungal agent, Application In Synthesis of 86386-77-8, the publication is European Journal of Medicinal Chemistry (2011), 46(7), 3167-3176, database is CAplus and MEDLINE.
In order to meet the urgent need for novel antifungal agents with improved activity and broader spectrum, a series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substituted trifluoromethyl phenyl)-piperazin-1-yl]-propan-2-ols I [R = alkyl, aryl, arylalkenyl, heteroaryl(alkenyl)] were designed, synthesized and evaluated as antifungal agents. The MIC80 values indicate that the compounds I [R = arylalkenyl, heteroaryl(alkenyl)] showed higher antifungal activities against Candida albicans than I [R = alkyl, aryl]. Moreover, the mol. model for the binding between compound I [R = Me, CH:CHPh] and the active site of CACYP51 was provided based on the computational docking results, and the structure-activity relationship was analyzed.
European Journal of Medicinal Chemistry published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Application In Synthesis of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics