New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C3H5N3
A solution of 4-methyl-1,2,4-triazole (1:08 g, 13 mmol) and DNPH (2:60 g, 13 mmol) in CH2Cl2 (20 mL) was stirred at 20 C for 4 d. The product precipitated and was collected by filtration, washed with CH2Cl2 (5 mL) and Et2O (5 mL), and dried to yield 2.45 g (67%) of a yellow powder. – 1H NMR (300 MHz, [D6]DMSO): delta = 3:84 (s, 3H), 6.32 (d, J =9:7 Hz, 1H), 7.41 (s, 2H), 7.77 (dd, J = 9.7 Hz, J = 3.1 Hz, 1H), 8.59 (d, J = 3.1 Hz, 1H), 8.98 (s, 1H), 9.98 ppm. – 13C NMR (75 MHz, [D6]DMSO): delta = 34:1, 125.0, 126.5, 127.4, 136.0, 140.7, 143.4, 170:3 ppm. – IR (neat): nu = 3294 w, 3236 w, 3081 m, 2988 m, 1595 s, 1550 m, 1525 s, 1475 m, 1431 m, 1371 m, 1307 s, 1258 s, 1175 m, 1128 s, 983 m, 834 s, 710 m, 654 m, 618 s cm-1. – C9H10N6O5 (282.21): calcd. C 38.30, H 3.57, N 29.78; found C 38.28, H 3.42, N 29.40.
We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 4-Methyl-4H-1,2,4-triazole ,and how the biochemistry of the body works.
Reference:
Article; Laus, Gerhard; Kahlenberg, Volker; Wurst, Klaus; Schottenberger, Herwig; Zeitschrift fur Naturforschung – Section B Journal of Chemical Sciences; vol. 69; 9-10; (2014); p. 950 – 964;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics