Related Products of 7170-01-6, New Advances in Chemical Research in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, molecular formula is C3H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Example 50. Synthesis of compound (R)-6-(4-chlorophenyl)-l,4-dimethyl-8-(5- methyl-lH-l,2,4-triazol-l-yl)-5,6- dihydro-4H-benzo[b][l,2,4]triazolo[4,3-d][l,4]diazepine (Compound 65) and (R)-6-(4-chlorophenyl)-l,4 -dimethyl-8-(3-methyl-lH-l,2,4-triazol-l- yl)-5,6-dihydro-4H-benzo[b][l,2,4]triazolo[4,3-d][l,4]diazepine (Compound 66). A mixture of (R)-8-bromo-6-(4-chlorophenyl)-l,4-dimethyl-5,6-dihydro-4H-benzo[b][l,2,4]triazolo [4,3- d][l,4]diazepine (60 mg, 0.15 mmol), 3-methyl-lH-l,2,4-triazole (14 mg, 0.16 mmol), copper (I) iodide (6 mg,0.03 mmol), 1,10-phenanthroline (11 mg, 0.06 mmol) and cesium carbonate (98 mg, 0.3 mmol) in dimethyl sulfoxide (3 mL) was heated at 130C for 30 minutes under microwave (pressure: 1.0 bar, equipment power : 150W). The reaction mixture was diluted with ethyl acetate (20 mL) and washed with brine (10 mL x 3). The organic phase was dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated to give a crude product which was purified by column chromatography (silica gel, dichloromethane/methanol = 20:1) to afford (R)-6-(4-chlorophenyl)- 1 ,4-dimethyl-8-(5-methyl- 1H- 1 ,2,4-triazol- l-yl)-5,6-dihydro-4H- benzo [b][l,2,4]triazolo[4,3-d][l,4]diazepine (15 mg, 25%) and (R)-6-(4-chlorophenyl)-l,4- dimethyl- 8-(3-methyl-lH-l,2,4-triazol-l-yl)-5,6-dihydro-4H-benzo[b][l,2,4]triazolo[4,3- d][l,4]diazepine (8 mg, 13%) as a light yellow solid.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 3-Methyl-1H-1,2,4-triazole.
Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; GEHLING, Victor, S.; HEWITT, Michael, C.; TAYLOR, Alexander, M.; HARMANGE, Jean-Christophe; WO2012/151512; (2012); A2;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics