Synthetic Route of 41253-21-8, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 271; Synthesis of N-(5-(lH-l.Z4-triazol-l-ylV2-f3A5-trimethoxybenzovn phenvPacetamide; As shown in Reaction 1, first, magnesium was added to l-bromo-3,4,5- trimethoxybenzene as a starting material. Then, Compound (VII) derivative was added thereto to obtain a compound [N-(5-fluoro-2-(3,4,5- trimethoxybenzoyl)phenyl)acetamide. Thus obtained compound [N-(5-fluoro-2- (3,4,5-trimethoxybenzoyl)phenyl)acetamide] (36.2mg, 0.1 mmol) was dissolved in DMF (2 ml), and 1,2,4-triazole-Na (28.5 mg) was added thereto at room temperature. The mixture was heated with stirring for 2 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and diluted with an EtOAc solution. The organic layer was washed with water, and brine. The extracted organic layer was dried over anhydrous MgSO4, and the solid substance was filtered off. The remaining solvent was removed by vacuum evaporation. The resulting residue was purified by column chromatography (SiO2, n-Hex/EA=2/l?l/l) to obtain Compound 271 (25.6 mg, 65%).1H NMR (CDCl3) delta 10.812 (s, IH), 9.077 (s, IH), 8.788 (s, IH), 8.144 (s, IH), 7.767 (d, J = 8.36 Hz, IH), 7.564 (d, J = 8.52 Hz, IH), 6.956 (s, 2H), 3.954 (s, 3H), 3.879 (s, 6H), 2.264 (s, 3H). MS (ESI) m/z 397 (M+ + H).
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about Sodium 1,2,4-triazol-1-ide.
Reference:
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; WO2008/38955; (2008); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics