An article Synthesis and application of amino triazolium-modified lactobionic acid as chiral selector in capillary electrophoresis WOS:000467665400021 published article about IONIC LIQUIDS; ENANTIOMERIC SEPARATION; BETA-CYCLODEXTRINS; ENANTIOSEPARATION; PERFORMANCE; COMPLEXES; MECHANISM; LIGAND; DRUGS; MODEL in [Liu, Jie; Du, Yingxiang; Sun, Xiaodong; Feng, Zijie; Ma, Xiaofei; Li, Jingtang] China Pharmaceut Univ, Dept Analyt Chem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Jiangsu, Peoples R China; [Du, Yingxiang] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China in 2019.0, Cited 39.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5. Computed Properties of C2H4N4
In this paper, a chiral selector, N-(4-H-1, 2, 4-triazolium)-lactobionamides (LA-ATM), was synthesized and applied for enantioseparation in capillary electrophoresis (CE) for the first time. Compared with lactobionic acid (LA) separation system, enhanced enantioseparation of five tested drugs was achieved in this modification system. In order to achieve good chiral separation, several parameters such as chiral selector concentration, buffer pH, applied voltage as well as the type and proportion of organic modifier were systematically investigated. Molecular modeling was applied to demonstrate the chiral recognition mechanism of the LA-ATM, which well supported the experimental results. Furthermore, a mathematical equation built up based on the molecular mechanics calculations was used in predicting resolution of tested drugs using LA or LA-ATM mediated CE, the predicted result was well correlated with the experimental result. (C) 2019 Published by Elsevier B.V.
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Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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