On November 23, 2016, Chen, Yuxue; He, Wenying; Song, Xinming; Wu, Luyong; Huang, Qinglan published a patent.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the patent was Method for preparing 4-aryl-NH-1,2,3-triazole from aldehyde sodium bisulfite adduct. And the patent contained the following:
The invention relates to method for preparing 4-aryl- NH-1,2,3-triazole I from aldehyde sodium bisulfite adduct. The method comprises the steps of: carrying out one-pot reaction of aldehyde sodium bisulfite adduct, nitro compound, sodium azide, solvent and additive for 1-10 h at 60-150 °C, and carrying out post treatment after reaction to obtain 4-aryl-NH-1,2,3-triazole. With cheap and easily available aldehyde sodium bisulfite adduct, nitro compound and sodium azide as raw materials, 4-aryl-NH-1,2,3-triazole compound is easily prepared Compared with existing method, the method provided in the invention has cheap and easily available raw material, simple operation and high reaction efficiency. Said 4-aryl-NH-1,2,3-triazole compound has the formula I as shown in the claim text, in which Ar is C5-C10 aryl or C5-C10 hetero aryl, and R is selected from H, C1-C6 alkyl, etc. Said aryl formaldehyde is benzaldehyde or naphthaldehyde, and hetero aryl formaldehyde is pyridylaldehyde or thiophene carboxaldehyde. Said nitro compound is nitro C1-C6 alkyl, nitro C2-C6 carboxylate or nitro C2-C6 nitrile. Said additive is selected from sodium sulfite, triethylamine, etc. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Safety of 4-(p-Tolyl)-1H-1,2,3-triazole
The Article related to preparing aryl triazole aldehyde sodium bisulfite adduct, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Safety of 4-(p-Tolyl)-1H-1,2,3-triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics