Total synthesis of anti-tuberculosis natural products Ilamycins E1 and F was written by Cheng, Yingying;Tang, Shoubin;Guo, Yian;Ye, Tao. And the article was included in Organic Letters in 2018.Reference of 156311-83-0 The following contents are mentioned in the article:
The first total synthesis of the potent anti-tuberculosis cyclopeptide natural products Ilamycins E1 and F was achieved. This highly convergent strategy consists of the synthesis of the two units (I) (Teoc = CO2(CH2)2TMS) and (II) (TBDPS = tert-butyltriphenylsilyl; TMSE = O(CH2)2TMS) and linking them together to form the macrocyclic lactam. The upper unit I was prepared from tryptophan in five steps, and the lower unit II was prepared from glutamic acid in thirteen steps. Conversion of Ilamycin F, the most abundant of the cyclopeptides, into the more active congener, Ilamycin E1, was also accomplished. This would provide sufficient material of Ilamycin E1 for more extensive biol. studies. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Reference of 156311-83-0).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. However, triazoles are also useful in bioorthogonal chemistry, because the large number of nitrogen atoms causes triazoles to react similar to azides.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Reference of 156311-83-0
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics