New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 13423-60-4, name is 1-Phenyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 13423-60-4
To 10 mL of chlorosulfonic acid at 0 C was added 1 g (6.9 mmol) of1-phenyl-1H-1,2,4-triazole, 35. The mixture was stirred overnight andthen cooled to 0 C. The solution was slowly added to ice and extracted3 three times with dichloromethane. The organic layers were combined,dried over sodium sulfate and concentrated to dryness in vacuo to give1 g of a tan solid. The crude sulfonyl chloride was used directlywithout further purification. To a microwave vial was added 25 mg(0.095 mmol) of the sulfonyl chloride, 15 mg (0.11 mmol) of 1,2,3,4-tetrahydroquinoline, 14 mg (0.014 mmol) of triethylamine and 300 muLof acetonitrile. The vial was sealed and heated at 130 C for 30 min. Themixture was diluted with dichloromethane and the organic phase waswashed 2 times with water and brine. The organic layer was dried oversodium sulfate and concentrated in vacuo. The crude sulfonamide waspurified by flash chromatography 0-75% EtOAc/Hexanes.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1-Phenyl-1H-1,2,4-triazole help many people in the next few years.
Reference:
Article; Okolotowicz, Karl J.; Dwyer, Mary; Ryan, Daniel; Cheng, Jiongjia; Cashman, Emily A.; Moore, Stephanie; Mercola, Mark; Cashman, John R.; Bioorganic and Medicinal Chemistry; vol. 26; 15; (2018); p. 4441 – 4451;,
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