Electric Literature of 1001401-62-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1001401-62-2 name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 2-(2H-1,2,3-triazol-2-yl)benzoic acid (285 mg, 1.5 mmol) in SOCl2 (3 mL) was stirred at RT for 0.5 h. Then the mixture was concentrated in vacuo. To a solution of the product from step 7 (300 mg, 1.26 mmol) and TEA (0.5 mL, 3.78 mmol) in DCM (3 mL) was added the above residue dropwise at 0 oC. The mixture was stirred at 0 oC for 2 h. water (2 mL) was added to quench the reaction and the mixture was extracted with DCM (3 mL x 3). The combined organic layers was washed with brine (3 mL x 3), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by Prep-HPLC to give the title compound as a solid. LRMS m/z (M+H) 410.1 found, 410.2 required.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; LIVERTON, Nigel; LUO, Yunfu; (68 pag.)WO2016/89721; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics