Adding a certain compound to certain chemical reactions, such as: 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1001401-62-2, Recommanded Product: 1001401-62-2
EXAMPLE 2 (2-(2H- 1 ,2,3-triazol-2-yl)phenyl)(4-(4,6-dimethylpyrimidin-2-yl)- 1 ,4-diazepan- 1 -yl)methanone To a solution of l-(4,6-dimethylpyrimidin-2-yl)-l,4-diazepane hydrochloride 1-2 (1.4 g, 5.2 mmol), 2-(2H-l,2,3-triazol-2-yl)benzoic acid Int E (1.1 g, 5.7 mmol), EDC (1.5 g, 7.8 mmol), and l-hydroxy-7-azabenzotriazole (1.1 g, 7.8 mmol) in DMF (10 mL) was added DIPEA (4.5 mL, 26 mmol) and the mixture was stirred at room temperature for 16 h. The solvent was concentrated in vacuo and the crude residue was redissolved in DCM and purified by silica gel chromatography (100% hexanes, 2 min; 0-100% EtOAc/hexanes, 20 min; 100% EtOAc, 4 min) to provide Example 2 (1.5 g) as a white solid. MS (ESI) m/z: 378.4 (M+H).
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Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; REGER, Thomas, S.; ROECKER, Anthony, J.; WO2015/95111; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics