Application of 107534-96-3, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 2 Preparation of 1-Tert-butyl-3-(p-chlorophenyl)-1-(1H-1,2,4-triazol-1-ylmethyl)propyl diphenylborinate STR11 A solution of diphenylborinic acid (0.11 g, 0.60 mmol) in toluene is added to a solution of 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol (0.21 g, 0.68 mmol) in a 1:1 ether/toluene solution. The reaction mixture is heated at reflux for 3 days with removal of water (Dean Stark), cooled and concentrated in vacuo to obtain a residue. The residue is chromatographed using silica gel and hexane/ethyl acetate solutions to give the title product as a pale yellow solid, mp 197 C.
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Reference:
Patent; American Cyanamid Company; US5591726; (1997); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics