Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1142927-05-6, name is 1-Methyl-1H-1,2,4-triazole-3-carbonitrile, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Methyl-1H-1,2,4-triazole-3-carbonitrile
1-methyl-3-cyano-1H-1,2,4-triazole (20 g, 185 mmol) and anhydrous methanol (500 mL) were added to 100 mL of dry three-Followed by the addition of sodium methoxide (14 g, 259 mmol) and amine chloride(14.8 g, 277.5 mmol),Stir at 5 C for 12 hThe filter,The filtrate was evaporated under reduced pressure,The residue was beaten with acetone,filter,A white solid (23.44 g, 78.8%) was obtained.
The synthetic route of 1142927-05-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhang Yingjun; Liu Xinchang; Ren Qingyun; Wang Chaolei; S ¡¤geerdeman; (50 pag.)CN103664899; (2017); B;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics