Reference of 16227-12-6, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, molecular formula is C8H7N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
EXAMPLE 131 4-phenyl-1-(tetradec-1-yl)-(1,2,4)-triazolium bromide 0.100 g (0.0007 mol) 4-phenyl-(1,2,4)-triazole 1 and 0.572 g (0.0021 mol) 1-bromotetradecane 2 are combined in a pressure tube. The reaction mixture is stirred 3 d at 110 C. To the resulted solid 10 ml petroleum ether was added. The product is filtered off, washed with petroleum ether/THF 1:1 and diethylether, and is dried in high vacuum. M 422.53 C22H36N3Br Yield: 0.242 g (74%) 1H-NMR DM-233 (300 MHz/DMSO): (ppm)=0.85 (t, 3H, 20-H); 1.24 (m, 24H, 9-19-H); 1.94 (q, 2H, 8-H); 4.42 (t, 21-1,7-H); 7.71 (m, 3H, 5/5’/6H); 7.82 (d, 2H, 4/4′-H); 9.78 (s, 1H, 1-H); 10.79 (s, 1H, 2-H) 13C-NMR DM-233 (75.475 MHz/DMSO):
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Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics