Electric Literature of 27996-86-7, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 27996-86-7, name is 4-[1,2,4]Triazol-1-yl-benzaldehyde, molecular formula is C9H7N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
A mixture of 4-(1H-1,2,4-triazol-1-yl)benzaldehyde(0.025 mol) and thiosemicarbazide (0.025 mol) in ethanol(40 mL) was refluxed for 12 h. The reaction mixture wascooled and filtered. The product was crystallized fromethanol.M.p. 284.2 C.IR nu max (cm-1): 3423.65, 3257.77 (N-H stretching),3120.82 (Aromatic C-H stretching), 2987.74 (Aliphatic C-Hstretching), 1602.85, 1541.12, 1516.05, 1465.90 (C=N, C=Cstretching and N-H bending), 1438.90, 1375.25, 1357.89 (CHbending), 1276.88, 1209.37, 1151.50, 1112.93, 1043.49(C-N, C=S stretching and aromatic C-H in plane bending),979.84, 958.62, 945.12, 891.11, 871.82, 829.39, 804.32,671.23, 605.65 (Aromatic C-H out of plane bending).1H NMR (400 MHz, DMSO-d6) delta (ppm): 7.89 (d, J= 9.2Hz, 2H), 7.99 (d, J= 8.4 Hz, 2H), 8.08 (d, J= 15.6 Hz, 2H),8.25 (s, 2H), 9.37 (s, 1H), 11.51 (s, 1H).MS (ESI) (m/z): (M+H)+ 247Anal. Calcd for C10H10N6S: C, 48.77; H, 4.09; N, 34.12.Found: C, 48.74; H, 4.11; N, 34.13.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about 4-[1,2,4]Triazol-1-yl-benzaldehyde, hurry up and to see.
Reference:
Article; Ciftci, Guel?en Akalin; Altintop, Mehlika Dilek; Temel, Halide Edip; Oezdemir, Ahmet; Kaplancikli, Zafer Asim; Letters in drug design and discovery; vol. 14; 5; (2017); p. 554 – 566;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics