Continuously updated synthesis method about 3,5-Dimethyl-4H-1,2,4-triazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

7343-34-2, A common compound: 7343-34-2, name is 3,5-Dimethyl-4H-1,2,4-triazole, belongs to Triazoles compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

4-chloro-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine (Intermediate 2) 4,6-dichloro-2-methylpyrimidine(2-1) (137.8 g, 845 mmol), 3,5-dimethyl-1H-1,2,4-triazole (2-2)[0080] (82 g, 845 mmol), and Cs2CO3 (275 g, 845 mmol) were suspended in DMF (1L) and the resulting mixture wasstirred at room temperature for 66 h. The mixture was then poured into water (2L) and stirred for 1 hour. The precipitatewas filtered, washed with water (2x) and dried under vacuum to afford Intermediate 2 as an off-white solid (130 g, 69percent).MS: m/z = 224.2 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Merck Sharp & Dohme Corp.; COX, Christopher, D.; BESHORE, Douglas, C.; KIM, June, J.; KUDUK, Scott, D.; McVEAN, Carol; REGER, Thomas; STEEN, Justin, T.; (54 pag.)EP2763672; (2016); B1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics