Adding a certain compound to certain chemical reactions, such as: 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41253-21-8, SDS of cas: 41253-21-8
First, 1H-1,2,4-triazole sodium salt (13.1 mmol) was dissolved in NMP (7 ml) and an internal temperature of thus obtained mixture was raised to 115C. Into this mixture, Compound IX-1 (8.76 mmol) was added and the mixture was washed with NMP (1.8 ml). Then, after the internal temperature rises back to 115C, sodium t-butoxide (5.26 mmol) and trimethylsulfoxonium bromide (1.476 mmol) were added in parts over approximately 3 hours. After addition of these sodium t-butoxide and trimethylsulfoxonium bromide had completed, stirring was carried out for 75 minutes at the internal temperature of 115C. Subsequently, after thus obtained reaction solution was cooled down to 35C, water was added to the reaction solution. Then, extraction with ethyl acetate was carried out. Further, an organic layer was washed with water and saturated brine, and dried with anhydrous sodium sulfate. Subsequently, a solvent was distilled away. Thereafter, by purification of a resultant residue by silica gel column chromatography, a target substance was obtained. [0291] Yield: 71%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Sodium 1,2,4-triazol-1-ide, and friends who are interested can also refer to it.
Reference:
Patent; Kureha Corporation; TATEISHI, Hideaki; ARAKI, Nobuyuki; YAMAZAKI, Toru; MIYAKE, Taiji; SUDO, Keiichi; KANNO, Hisashi; EP2719281; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics