6523-49-5,Some common heterocyclic compound, 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, molecular formula is C8H8N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of formamidine from Step 1 (151 mg) and 4-triazolylaniline(100 mg) in AcOH (5 ml) were heated to 125 for 3 h. The cooled reaction mixture was basified with 2N NaOH and the precipitate isolated by filtration and purified by column chromatography on silica gel with DCM:MeOH (2.5%) as eluant. This gave the title compound (200 mg).1H NMR delta 10.1 (IH, s), 9.3 (IH, s), 8.83 (IH, s), 8.63 (IH, s), 8.26 (IH, s), 8.19 (IH, d, J 8.85Hz), 8.07 (2H, d, J 8.85Hz), 7.92 (2H, d, J 8.85Hz), 7.85 (IH, d, J8.85Hz), 7.76 (IH, d, J 2.5Hz), 7.70 (IH, d, J 5Hz), 7.27 (IH, m); LC-MS rt 2.39 m/z369 ES-.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(1,2,4-Triazol-1-yl)aniline, its application will become more common.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics