Reference of 6523-49-5, These common heterocyclic compound, 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Formamidine from step 1(2.96 g, 9.6 mmol) and 4-triazolylaniline (1.54 g, 9.6 mmol) in AcOH (10 ml) were heated to reflux for 3 h. The cooled solution was diluted with ether (200 ml) and the resulting precipitate filtered off. The filter cake was washed with ether, dried under suction then slurried with 2N NaOH (100 ml) with stirring for 30 minutes. The resulting solid was again isolated by filtration, washed with water and dried to give a pale yellow solid (3.81 g, 93 %). 1H NMR deltaltheta.11 (IH, s), 9.30 (IH, s), 8.80 (IH, s), 8.65 (IH, s), 8.26 (IH, s),8.23 (IH, s), 8.10 (2H, d, J 10Hz)5 7.92 (2H5 d, J 10Hz ), 7.88 (IH, d, J7.5Hz), 7.47 (2H, overlapping s), 7.16 (IH, d, J7.5Hz), 3.93 (3H, s), 3.85 (3H, s); LC-MS rt 2.17 m/z 425 ES+.
The synthetic route of 6523-49-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics