Synthetic Route of 6523-49-5, New discoveries in chemical research and development in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Chloro-6-iodoquinazoline (WO9609294 Al , 150 mg) was treated with 4- triazolyl aniline (28 mg, 1 eq) in MeCN and refluxed for 6 h. Cooled overnight and filtered to give the title compound (70 mg).1R NMR delta 11.75 (IH, br s), 9.4 (2H, s), 9.04 (IH, s), 8.43 (IH, d, J 8.85Hz),8.34 (IH, s), 8.0(4H, m), 7.82 (IH, d, J 8.85Hz); LC-MS rt 2.32 m/z 415 ES+.
The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.I hope my blog about 4-(1,2,4-Triazol-1-yl)aniline is helpful to your research.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics