Synthetic Route of 7343-33-1,Some common heterocyclic compound, 7343-33-1, name is 5-Bromo-1H-1,2,4-triazole, molecular formula is C2H2BrN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of the intermediate 5 300 mg, potassium carbonate 133 mg and N,N-dimethylformamide 3 mL was added 3-bromo-1H-1,2,4-triazole 132 mg at 0¡ãC. The mixtures were stirred at 0¡ãC for 2.5 hours and to the reaction mixture was added saturated aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic layers were washed with water and brine and dried over anhydrous sodium sulfate. The resulting organic layers were concentrated under reduced pressure. The resulting residues were subjected to a silica gel column chromatography to give the following present compound 3 370 mg. H1-NMR (CDCl3) delta: 9.04 (1H, s), 8.81 (1H, br s), 8.73 (1H, d), 8.35 (1H, br s), 8.26 (1H, d), 3.92 (3H, s), 3.81 (2H, q), 1.39 (3H, t).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-1H-1,2,4-triazole, its application will become more common.
Reference:
Patent; Sumitomo Chemical Company, Limited; TANABE, Takamasa; MIZUNO, Hajime; OKAMOTO, Hiroshi; (41 pag.)US2017/135348; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics