The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone( cas:86404-63-9 ) is researched.Safety of 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone.Lebouvier, Nicolas; Giraud, Francis; Corbin, Typhanie; Na, Young Min; Le Baut, Guillaume; Marchand, Pascal; Le Borgne, Marc published the article 《Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents》 about this compound( cas:86404-63-9 ) in Tetrahedron Letters. Keywords: indolyl triazolylpropanol preparation; chloroacetophenone triazole substitution microwave irradiation; triazolylacetophenone preparation epoxidation microwave irradiation; microwave irradiation substitution Corey Chaykovsky epoxidation mediator; aryl triazolylmethyl oxirane preparation indole ring opening. Let’s learn more about this compound (cas:86404-63-9).
Conazole antifungals, in the series of triazole alcs., e.g., I, have been synthesized by ring opening of corresponding oxiranes, e.g., II. These oxiranes were prepared in high yields by Corey-Chaykovsky reaction under microwave irradiation
There is still a lot of research devoted to this compound(SMILES：FC1=CC=C(C(CN2N=CN=C2)=O)C(F)=C1)Safety of 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone, and with the development of science, more effects of this compound(86404-63-9) can be discovered.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics