Related Products of 930-33-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 930-33-6, name is 1H-1,2,4-Triazol-3(2H)-one belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 5 3-[6-Bromo-2-fluoro-3-(5-oxo-1,5-dihydro-[1,2,4]triazol-4-ylmethyl)-phenoxy]-5-chloro-benzonitrile (I-8) Ar=3-chloro-5-cyano-phenyl A solution of A-2d (200 mg, 0.477 mmol), 2,4-dihydro-[1,2,4]triazol-3-one (10, CASRN 930-33-6, 0.040 g, 1.0 eq), K2CO3 (0.13 g, 2.0 eq), and KI (0.008 g, 0.1 eq) and MeCN (1.5 mL) was heated to 85 C. for 2 h and then cooled to RT. The reaction mixture was diluted with 10% MeOH/DCM, and washed sequentially with water and brine. The organic extracts were evaporated and the crude product purified by SiO2 chromatography eluding with a MeOH/DCM gradient (3-10% MeOH) to afford 0.020 g (10%) of 1-8 as a white solid.
The synthetic route of 1H-1,2,4-Triazol-3(2H)-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Roche Palo Alto LLC; US2009/12034; (2009); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics