Cui, Xue; Ma, Jianting; Zeng, Tingting; Xu, Junyu; Li, Youbin; Wang, Xuesong published their research in RSC Advances in 2021. The article was titled 《Metal-free cascade synthesis of unsymmetrical 2-aminopyrimidines from imidazolate enaminones》.Formula: C2H3N3 The article contains the following contents:
A convenient metal-free synthesis of unsym. 2-aminopyrimidines I [R1 = cyclopropyl, Ph, 4-MeC6H4, etc.; R2 = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] from imidazolate enaminones had been developed. In this procedure, various structural 2-aminopyrimidines I, as well as 4,5-dihydroisoxazol-5-ols and pyrazoles were synthesized in moderate to excellent yields. A plausible mechanism was also proposed for the cascade reaction. This method represented an effective strategy toward the synthesis of unsym. 2-aminopyrimidines I. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics