Decrypt The Mystery Of 3222-47-7

Compounds in my other articles are similar to this one(6-Methylnicotinic acid)Name: 6-Methylnicotinic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Generating Multibillion Chemical Space of Readily Accessible Screening Compounds》. Authors are Grygorenko, Oleksandr O.; Radchenko, Dmytro S.; Dziuba, Igor; Chuprina, Alexander; Gubina, Kateryna E.; Moroz, Yurii S..The article about the compound:6-Methylnicotinic acidcas:3222-47-7,SMILESS:O=C(O)C1=CN=C(C)C=C1).Name: 6-Methylnicotinic acid. Through the article, more information about this compound (cas:3222-47-7) is conveyed.

An approach to the generation of ultra-large chem. libraries of readily accessible (‘REAL’) compounds is described. The strategy is based on the use of two- or three-step three-component reaction sequences and available starting materials with pre-validated chem. reactivity. After the preliminary parallel experiments, the methods with at least ~80% synthesis success rate (such as acylation – deprotection – acylation of monoprotected diamines e.g., 1-boc-amino-butyl-3-amine or amide formation e.g., N-(9-acetyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide – click reaction with functionalized azides e.g., 3-(azidomethyl)-piperidine) can be selected and used to generate the target chem. space. It is shown that by using only on the two aforementioned reaction sequences, a nearly 29-billion compound library is easily obtained. According to the predicted physico-chem. descriptor values, the generated chem. space contains large fractions of both drug-like and ‘beyond rule-of-five’ members, whereas the strictest lead-likeness criteria (the so-called Churcher’s rules) are met by the lesser part, which still exceeds 22 million.

Compounds in my other articles are similar to this one(6-Methylnicotinic acid)Name: 6-Methylnicotinic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics