Reference of 3179-31-5, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 3179-31-5, name is 1H-1,2,4-Triazole-3-thiol, molecular formula is C2H3N3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
c) 6-Chloro-2-[4-(lJH-l,2,4-triazol-3-ylthio)-l-piperidinyl]-iV-(tricyclo[3.3.1.13’7]dec-l- ylmethyl)-5-quinolinecarboxamide; To 6-chloro-2-[4-[(methylsulfonyl)oxy]-l-rhoirhoeridinyl]-N-(tricyclo[3.3.1.13’7]dec-l- ylmethyl)-5-quinolinecarboxamide (200 mg) (Example 22 (b)) and potassium carbonate 5 (104 mg) in acetone (2 mL) and water (0.3 mL) was added IH- l,2,4-triazole-3 -thiol (57 mg). The mixture was heated in a microwave for 40 minutes at 1200C and then cooled to room temperature. The solvent was removed under vacuum and the reaction worked up as described in (Example 22 (b)) to afford the sub-titled compound (220 mg).I0 MS: APCI(+ve) 538/540 (M+H*).
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Reference:
Patent; ASTRAZENECA AB; WO2006/59945; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics