Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 7170-01-6
Step A. 2-Chloro-4-(3 -methyl-i H-i ,2,4-triazol- 1 -yl)benzaldehydeTo a solution of 2-chloro-4-fluorobenzaldehyde (95 mmol, 15 g) and 3-methyl-1H-i,2,4-triazole(114 mmol, 9.4 g) in CH3CN (300 mL) was added K2C03 (142 mmol, 20 g) and stirred at 60 C.After 24 h, the reaction mixture was added water and extracted with EtOAc. The organic extracts washed with saturated aq. NaC1, dried over Na2SO4, and filtered and concentrated in vacuo. The crude was purified by column chromatography (heptane :EtOAc = 20:80-10:90) to give the title compound. MS (ESI) mlz = 222, 224 (M+H)?H NMR (300 MHz, CDC13) 5 (ppm): 10.45 (1H, s), 8.55 (1H, s), 8.06 (1H, d, J 8.6 Hz), 7.87(1H, d, J= 2.1 Hz), 7.68 (1H, dd, J 8.6, 2.1 Hz), 2.51 (3H, s).
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 7170-01-6.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MOCHIDA PHARMACEUTICAL CO., LTD.; SAKURADA, Isao; HIRABAYASHI, Tomokazu; MAEDA, Yoshitaka; NAGASUE, Hiroshi; MIZUNO, Takashi; XU, Jiayi; ZHANG, Ting; SMITH, Cameron; PARKER, Dann; WO2015/160636; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics