Weber, Philip; Rank, Christian K.; Yalcinkaya, Enis; Dyga, Marco; van Lingen, Tim; Schmid, Rochus; Patureau, Frederic W.; Goossen, Lukas J. published the article 《Rhodium-catalyzed ortho-Arylation of (Hetero)aromatic Acids》. Keywords: carboxylate heteroaryl preparation; heteroaryl aryl carboxylic acid preparation regioselective methyl iodide esterification; bromide aryl heteroaryl carboxylic acid arylation.They researched the compound: 6-Methylnicotinic acid( cas:3222-47-7 ).Recommanded Product: 3222-47-7. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:3222-47-7) here.
Rhodium acetate effectively promotes the carboxylate-directed ortho-arylation of (hetero)aromatic carboxylic acids ArCOOH (Ar = 2-methylphenyl, 4-methoxythiophen-3-yl, 2-fluoropyridin-3-yl, etc.) with aryl bromides Ar1Br (Ar1 = 4-methylphenyl, 2-naphthyl, 2-methylpyridin-6-yl, etc.) yielded functionalized hetero/aryl carboxylic acids, e.g., I (X = H, Me) and its Me carboxylates. The main advantage of this phosphine-free, redox-neutral method arises from its efficiency in assembling biol. meaningful electron-rich arylpyridines, which are problematic substrates in known C-H arylations using Pd, Ru, and Ir catalysts.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics