Related Products of 956317-36-5, New Advances in Chemical Research in 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, molecular formula is C10H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
In the 50 L reaction flask A,10 kg of 5-methyl-2- (1,2,3-triazol-2-yl) benzoic acid,1.5 L dichloromethane,Ice bath to 0 ,Under nitrogen, 640 g of oxalyl chloride was added,100 g of DMF,The reaction was stirred at room temperature for 2 h.In another 100L reaction flask B,1.25 kg of compound 6 was added,1 kg of triethylamine,30 L of dichloromethane,Stir at room temperature for 2h and then cool the ice bath to 0 C,Dropping the mixture in the reaction flask A,Drop finished,Placed at 10 C,HPLC monitoring. After the reaction,The reaction solution was diluted with water,And then extracted with DCM,The DCM phase was dried over anhydrous sodium sulfate,And finally concentrated under reduced pressure at 45 C to obtain a crude product,The crude product was passed through a column of silica gel (60-120 mesh)The eluent was a 2% methanol / dichloromethane system,The compound 7 was concentrated in a brown oily liquid,Weight 1.98 kg, yield: 88%.
Therefore, this conceptually novel strategy might open impressive avenues to establish green and sustainable chemistry platforms.In my other articles, you can also check out more blogs about 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid.
Reference:
Patent; Chengdu Meiyugao Pharmaceutical Co., Ltd.; Chen Zhiyong; Wang Chunyan; Wang Cong; (26 pag.)CN106866632; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics