Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 77-85-0, Name is 1,1,1-Tris(hydroxymethyl)ethane, molecular formula is C5H12O3, belongs to Triazoles compound. In a document, author is Abu-Hashem, Ameen Ali, introduce the new discover, Recommanded Product: 77-85-0.
Synthesis of new pyrazoles, oxadiazoles, triazoles, pyrrolotriazines, and pyrrolotriazepines as potential cytotoxic agents
4-Oxo-4-phenylbutanehydrazide (1) reacted with many active methylene reagents such as acetylacetone, diethylmalonate, ethylacetoacetate, ethylcyanoacetate, benzoyl-acetonitrile, and malononitrile under neat conditions to afford the corresponding pyrazoles (2-7), also, treatment of butanehydrazide (1) with electrophilic reagents as triethylorthoformate, dimethylformamide-dimethylacetal, acetic anhydride, and carbon disulfide to give 1,3,4-oxadiazoles (8,10,11) and N ‘-acetyl-butanehydrazide (9). Reacted of butanehydrazide (1) with potassium thiocyanate gave 1,2,4-triazoles (12). Similarly, treatment of (1) with chloroacetamide gave 1,2,4-triazinones (13). The pyrrolotriazinones (14) was obtained by cyclization of (13). Also, butanehydrazide (1) was utilized as a starting material for the synthesized of new Schiff bases as N ‘-(4-sub-benzylidene)-phenylbutane-hydrazide (15a-c), which are used as an initiative to prepare new compounds such as 1,2,4-triazepinones (16a-c), pyrrolotriazepinones (17a-c), 1,2,4-triazines (18a-c), and pyrrolotriazines (19a-c) by reacted of (15a-c) with each chloroacetamide or formamide. The chemical structure of the newly prepared compounds was determined through the spectrum data, including IR, NMR, and MS. The prepared compounds were tested for their in vitro antitumor activities. The compounds 17a-c, 16a-c, and 19a-c displayed activity against several types of cancer cell lines.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 77-85-0. Recommanded Product: 77-85-0.