Electric Literature of 151899-62-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 151899-62-6, name is 3-Iodo-1-trityl-1H-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
3-iodo-1-trityl -1H-1,2,4- triazole (300 mg),3-cyanophenyl boronic acid (101 mg), tetrakis triphenylphosphine palladium (79 mg), ethanol 2M aqueous sodium carbonate (1.5 mL) (1.0 mL) – toluene (1.5 mL) mixed solution of the mixture was stirred for 4 hours at 100 C. After cooling to room temperature, and separated the two layers.The aqueous layer was extracted with ethyl acetate, it was concentrated under reduced pressure and the organic layers were washed with. The residue was purified by column chromatography (silica gel cartridge, hexane: ethyl acetate = 88: 12-50: 50) to give the title compound (227 mg) as a colorless solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-trityl-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; KONISHI, KAZUHIDE; KANUMA, KOSUKE; NAKAMURA, TOSHIO; AMADA, HIDEAKI; YAMAMOTO, SHUJI; KASHIWA, SHUHEI; MASUDA, SEIJI; OKADA, KUMIKO; KAWAMOTO, HIROSHI; (74 pag.)JP2015/78127; (2015); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics