Synthetic Route of 16681-70-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16681-70-2 name is 1H-[1,2,3]Triazole-4-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[0760] lH-1,2,3-triazole-4-carboxylic acid (2.6 mg, 23f.tmol) was combined with HATU (9.6 mg, 25 flillOl) in DMF(3.0 mL) and stirred at room temperature for 15 minutes.Compound 2 (13 mg, 29 f.tmol) was dissolved in DIPEA (12f.LL, 69 f.tmol) and combined with the activated acid solution.The mixture was stirred at room temperature for 15 minutes,after which time LCMS indicated desired product formation.The solvent was removed in vacuo and the crude residue waspurified by reverse phase chromatography to yield Compoundb (0.8 mg) as a TFA salt. MS m/z [M+Ht calc’d forC25H27ClF3N50 3 , 538.18. found 538.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-[1,2,3]Triazole-4-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics