Adding a certain compound to certain chemical reactions, such as: 288-36-8, name is 1H-1,2,3-Triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-36-8, 288-36-8
A mixture of 2-chloro-5-nitropyridine-3-carbonitrile (9.0 g, 49 mmol), 2H-[1,2,3]Triazole (3.41 mL, 58.8 mmol) and potassium carbonate (20.32 g, 147 mmol) in acetonitrile (225 mL) was stirred at 30 C. for 2 h. Water and ethyl acetate were added and the organic phase was separated, dried with MgSO4, filtered and the filtrate concentrated to afford the crude product, which was mixed with dichloromethane (30 mL) and filtered to afford pure 5-nitro-2-[1,2,3]triazol-2-yl-nicotinonitrile (8.3 g, 78.4% yield) as an orange solid. 1H NMR (300 MHz, DMSO-d6) delta 8.46 (s, 2H), 9.45 (d, J=2.5 Hz, 1H), 9.61 (d, J=2.5 Hz, 1H). LC-MS m/z 217.0 (M+H)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Janssen Pharmaceutica NV; Lu, Tianbao; Connolly, Peter J.; Cummings, Maxwell David; Barbay, Joseph Kent; Kreutter, Kevin D.; Wu, Tongfei; Diels, Gaston Stanislas Marcella; Thuring, Jan Willem; Philippar, Ulrike; Edwards, James Patrick; Shen, Fang; (202 pag.)US2019/381019; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics