Some common heterocyclic compound, 288-36-8, name is 1H-1,2,3-Triazole, molecular formula is C2H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1H-1,2,3-Triazole
Intermediate D 2-(2H)-l ,2,3-Triazol-2-yl)thiophene-3-carboxylic acid Intermediate D A solution of 2-bromo-3-thiophene carboxylic acid (1.50 g, 7.24 mmo’ 1 ,2,3-triazole (0.600 g, 8.69 mmol), potassium carbonate (2.00 g, 14.5 mmol), and copper(I) iodide (0.138 g, 0.724 mmol) in DMF (36.2 mL) was sparged with nitrogen and heated to 75 C for 96 h. The cooled reaction mixture was diluted with water and washed with ether. The aqueous layer was acidified with cone. HCl. The acidic aqueous solution was extracted 3x with EtOAc and the combined organic fractions were washed with brine, dried over MgSC>4, filtered, and concentrated in vacuo. The crude material was purified by silica gel chromatography [0- 70% (1 % acetic acid in EtOAc) in hexanes] to provide the title compound. LRMS m/z (M+H) 196.2 found, 196.1 required.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288-36-8, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KIM, Ronald; KUDUK, Scott, D.; LIVERTON, Nigel; ZHUO, Gang; (116 pag.)WO2016/100161; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics