Synthetic Route of 288-88-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 288-88-0 name is 1H-1,2,4-Triazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add 1,2,4-triazole (17.44 g, 252.5 mmol),Sodium hydroxide (10.4g, 259.9mmol),2.8 g of triethylbenzyl ammonium chloride and 10 g of N, N-dimethylformamide were put into a reaction flask,After preheating to 80 C,Started the dropwise addition of 2- (4-chlorophenethyl) -2-tert-butylethylene oxide (59.1 g, 247.5 mmol),Control temperature ?95 during dropping,After the addition,Incubate at 98 102 for 2 3h,After the incubation period, add a water layer, wash the organic layer with water to pH <8, and after the organic layer is desolved under negative pressure,74.5 g of finished tebuconazole is obtained,Content 97.8%,The yield was 95.6%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1H-1,2,4-Triazole, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Qi Zhou Green Chemical Co., Ltd.; Chen Jia; Jiang Yuhua; Zhou Wei; Cai Junyi; Ding Fei; (6 pag.)CN110563660; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics