In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 584-13-4 as follows. 584-13-4
5-(4J-l,2,4-Triazol”4-ylamino)-4I-(beiizyIoxy)biphenyl-2-carbonitriIe (CAB06050)To a solution of 4/?-l,2,4-triazol-4-amine (2.439 g, 29.01 mmol) in DMSO (50 mL) was added KOtBu (336 g, 30.0 mmol). The mixture was stirred for 0.5 hours at room temperature before CAB06Theta48 (4.40 g, 14.51 mmol) was added and stirring was continued for 1 hour. The mixture was poured into crashed ice and neutralized with 2M BCHSO4 solution. The precipitate was filtered off and recrystallised from EtOAc/?-hexane to give CAB06050 (5.07 g, 85%) as fine colorless needles. Mp. 180-182 0C; 1H NMR (400 MHz, DMSO-rftf) delta 5.17 (s, 2H)5 6.47 (d, J = 2.4 Hz5 IH), 6.54 (dd, J = 8.6, 2.4 Hz, IH)5 7.15 (AA’BB’, 2H), 732-7.50 (m, 7H)5 7.78 (d, J= 8.6 Hz, IH), 8.86 (s, 2H), 10.28 (S5 IH); 13C NMR (100.6 MHz5 DMSO-rf*) delta 69.4, 101.2, 111.0, 1123, 115.0, 119.1, 127,8, 127.9, 128.5, 129.7, 130.2, 135.6, 136.8, 144.1, 146.0, 150.8, 158.9; LRMS (ES+): m/z 368,2 (100%, [M+H]+); HRMS (ES+) calcd for C22H18N5O [M+H]+: 368.1506, found 368.1494.
According to the analysis of related databases, 584-13-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; STERIX LIMITED; WOO, Lok Wai Lawrence; BUBERT, Christian; WOOD, Paul Michael; PUTEY, Aurelien; PUROHIT, Atul; POTTER, Barry Victor Lloyd; WO2011/23989; (2011); A1;,
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